55.3% of California births are to mothers age 30+. In San Francisco? 82.5%.pic.twitter.com/fdP4cxFAVR
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Those stats for Down syndrome, which is the most common disorder resulting from a chromosomal abnormality. Not all of them are as easy to study, which is why it's often used as a reference for understanding relative risk. Here are 150+ more: https://rarediseases.info.nih.gov/diseases/diseases-by-category/36/chromosome-disorders …
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Thankfully it's a screenable one, at least. Also, I was surprised to learn that paternal age is now thought to contribute around 50% of chromosomal risk in these 40+ maternal age pregnancies; the maternal odds we have are likely tainted by men being older: https://www.theatlantic.com/health/archive/2015/11/genetic-screening-down-syndrome-fathers/415320/ …
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Good reasons to consider using an egg or sperm donor at that point, which may be prudent anyway due to fertility issues. In any case, paternal age doesn't appear to be a risk factor in non-geriatric pregnanciespic.twitter.com/8eBS96qUAi
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