55.3% of California births are to mothers age 30+. In San Francisco? 82.5%.pic.twitter.com/fdP4cxFAVR
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Not so minimal.
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Those stats for Down syndrome, which is the most common disorder resulting from a chromosomal abnormality. Not all of them are as easy to study, which is why it's often used as a reference for understanding relative risk. Here are 150+ more: https://rarediseases.info.nih.gov/diseases/diseases-by-category/36/chromosome-disorders …
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Coincidentally, I saw a graph of the age of a man vs the age of women he finds most attractive. Almost all men of all ages were most attracted to women aged 20-25. Cultural influence or just nature being nature?
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Why is 45 higher than 50?
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Likely just an insufficient sample size that far into the tail. Very, very few women are able to get pregnant at 50.
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Why is this worse with age?
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Aging gametes seem spell trouble for healthy cell division, though I don't know the mechanism. Using frozen "young" eggs or donor eggs eliminates the risk, even at an advanced maternal age
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Is this effect additive? In other words, if the child of 40 year old parents has their own kids at 40, are the risks even higher? (Like repeated cousin marriage from generation to generation makes things worse)
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Those are not accurate. What’s your source? Most OBGYNs have updated their guidance regarding the latest studies which, while it increases the chances, it increases the chance of the chance which is very tiny.
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