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virusmonologues's profile
The Virus Monologues✊🏾🇵🇸
The Virus Monologues✊🏾🇵🇸
The Virus Monologues ✊🏾 🇵🇸
@virusmonologues

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The Virus Monologues ✊🏾 🇵🇸

@virusmonologues

All things viruses.. and other nasties: systemic racism. PS:Racism is taught, not caught Wendy Burgers: Viral immunologist, A/Prof @IDM, University of Cape Town

Cape Town, South Africa
Joined August 2016

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    1. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      If we plot fold-change of Omicron responses compared to ancestral, we see that 70-80% of T cell responses are preserved. This means that most people who were vaccinated with 1x / 2xJnJ, 2xPfizer & those who had COVID 1-6 mo ago, still have T cells that can recognise Omicron.pic.twitter.com/F6UUBIYZ2o

      5 replies 78 retweets 246 likes
      Show this thread
    2. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      Important to point out - there were a minority of CD8 T cell “knockouts”. These represent people who may have had a narrower response targeting only a few regions in Spike, that happened to coincide with mutations in Omicron and a specific HLA bkg – we’ll be following up on these

      1 reply 31 retweets 171 likes
      Show this thread
    3. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      When we compared the cross-reactivity of T cells to Omicron with Beta and Delta variants, we found that they were very similar, even though Omicron has 3-4x more spike mutations than Beta and Delta. This emphasises just how robust the T cell response is.pic.twitter.com/YaneWZAxfU

      1 reply 43 retweets 203 likes
      Show this thread
    4. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      This is consistent with what we recently published on cross-reactivity of the T cell response to the Beta variant: https://www.science.org/doi/epdf/10.1126/scitranslmed.abj6824 …pic.twitter.com/jRbNZLeDn5

      2 replies 28 retweets 157 likes
      Show this thread
    5. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      To get a full picture of immunity, @sigallab and @PennyMo70026063 measured neutralising antibody responses in the same participants. You can see that while neutralisation is substantially decreased in most people, overall their T cell responses are only impacted in a small way.pic.twitter.com/kMelvgXj3O

      1 reply 38 retweets 177 likes
      Show this thread
    6. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      South Africa’s COVID epidemic is characterised by virologically distinct waves, each dominated by a different form of the virus – first original, then Beta, Delta and now Omicron. Next we tested blood samples from each wave & compared them to patients from the 4th wave (Omicron)pic.twitter.com/lGJpwq0G3j

      1 reply 26 retweets 160 likes
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    7. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      We measured T cell responses to Spike, Nucleocapsid and Membrane proteins (viral proteins most targeted by T cells when you become infected). Omicron-infected patients had T cell responses in the same range as patients hospitalised with ancestral, Beta or Delta virus infection.pic.twitter.com/hFx2sERU8n

      1 reply 28 retweets 153 likes
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    8. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      Finally, we also tested some Omicron-infected patients with ancestral and Omicron Spike, and there was hardly any difference between them, showing that most of the parts of Spike that people make T cell responses to are conserved - parts that are not affected by the mutations.pic.twitter.com/y0zc8eK5SB

      1 reply 37 retweets 166 likes
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    9. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      Conclusions: Despite Omicron having so many mutations, and lower antibody activity, the majority of T cell responses, from vaccination or infection, cross-recognise the new variant.

      2 replies 115 retweets 360 likes
      Show this thread
    10. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      The limited effect of Omicron’s mutations on the T cell response suggests that vaccination or prior infection may still provide protection from severe disease

      2 replies 60 retweets 264 likes
      Show this thread
      The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

      Well-preserved T cell immunity to Omicron is consistent with early clinical observations from South Africa, UK and Scotland of lower severity - a decoupling of case loads from hospitalisations, and shorter hospital stays, which may be due to this remaining T cell immunity

      8:01 AM - 29 Dec 2021
      • 61 Retweets
      • 289 Likes
      • Für die Gerechtigkeit 水瀬(Mizuse) Penulis Kacamata✨ Steeven Yeh Apoorva 🇮🇳🌊🌦️💃 Atilla Can Akash Mukherjee Daniel Charbonniere 🌺 Piero B 🇮🇹🇪🇺 I'M Scudetto 🖤💙 Farhan Yusuf
      6 replies 61 retweets 289 likes
        1. New conversation
        2. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

          Finally: The resilience of the T cell response demonstrated here also bodes well in the event that more highly mutated variants emerge in the future. We still need to see how long T cell immunity lasts, but after SARS1 it was still detectable after 17yrs..https://www.nature.com/articles/s41586-020-2550-z …

          10 replies 81 retweets 381 likes
          Show this thread
        3. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

          Who did the work? 🔬🧪🩸😓 Dr Roanne Keeton is the amazing researcher who generated much of the T cell data, along with my lab team, and I co-led this work with the brilliant Dr Catherine Riou.

          3 replies 35 retweets 290 likes
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        4. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

          This work was also made possible by wonderful collaborators, esp. @Ntobekon and @SetteLab, @VreemdeSiekteDr, @sigallab, @PennyMo70026063, @tuliodna, @Alba_Grifoni, @BhimanJinal, @LindaGailBekker, @houzhou, @just_Thande, @KhadijaKhan24 and many others who contributed to this work

          6 replies 21 retweets 209 likes
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        5. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

          Thank you to all the volunteers and patients who made this work possible, and our funders @MRCza @EDCTP @CIDRI_Africa @UCTIDM @UCT_news @wellcometrust

          1 reply 15 retweets 171 likes
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        6. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

          Shout out to @Biocair for all their efforts in getting critical reagents to us when they were stuck in Dubai because of NONSENSICAL TRAVEL BANS

          2 replies 19 retweets 183 likes
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        7. The Virus Monologues ✊🏾 🇵🇸‏ @virusmonologues 29 Dec 2021

          And for those who may be interested in our work: @GuptaR_lab @EricTopol @apoorva_nyc @GretchenVogel1 @Williams_T_C @KatherineJWu @krisp_news @jessbreadman

          14 replies 14 retweets 136 likes
          Show this thread
        8. End of conversation
        1. New conversation
        2. Marta Bonn‏ @BonnMarta 29 Dec 2021
          Replying to @virusmonologues

          @threadreaderapp please unroll. Thank you

          1 reply 0 retweets 0 likes
        3. Thread Reader App‏ @threadreaderapp 29 Dec 2021
          Replying to @BonnMarta

          Hello, you can read it here: We have new results on T cell responses to #Omicron, and its good… https://threadreaderapp.com/thread/1476221647417921536.html … Enjoy :) 🤖

          0 replies 2 retweets 6 likes
        4. End of conversation
        1. New conversation
        2. Aida Vaxxed, Boosted, Masked.Yep I'm a superhero‏ @agninri 29 Dec 2021
          Replying to @virusmonologues

          I know this is a pre-print but i really feel like dancing for joy. This is good news.

          1 reply 1 retweet 4 likes
        3. Show replies

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