1. Some lose agency through complacency
2. Some have it taken from them by force
3. Some never had any to begin with, or a realistic shot at gaining any
4. And some reject it as a sinful thing to possess
You're allowed to make jokes about 1 and 4. Especially 4.
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If everything is the result of prior causes over which the person had no control then they are off limits for jokes regardless of the number.
If only I could refrain from giving in to the temptation....
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