Oxymetazoline (Afrin) is amazing and scary stuff. Makes older decongestants seem like junk. But the rebound effect is real and bad.
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Reading about how it helps my nose clear up is what made me interested in sneezing dogs. Strangely this study came out in 1988 but no one seemed to notice.
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They tested against opossum kidney cells (a common set of cells for research at the time) and it seemed to shut off Adenylyl cyclase by how it acts on serotonin receptors. Finding suggest it's an agonist for that receptor (which I think is how it makes my nose run/produce mucus).
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