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Is there a way to estimate the "worst reachable mutation" from the base virus, so we know how bad it *could* get? What's the worst possible variant?
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Replying to @vgr
Sounds like protection from severe illness/death is not fading (yet?).. what I am somewhat hopeful for is that the delta variant is already pretty close to the peak of the fitness space for this family of viruses
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There isn’t really. Not in the way you can estimate in more analytically tractable systems (eg thermodynamically governed). It’s analogous to “how bad can an economic collapse get with a set of systemically bad securities?”
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