Exactly what I’ve been wondering. What’s to stop corona from going rhino and evolving 160 subtypes and effectively DDoSing us with variety, BUT remaining more dangerous than both colds and flus? We’ve got 4 mild and 3 severe coronaviruses already.https://twitter.com/Incept_shawn/status/1317932857256480769 …
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From first QT, sounds like most cold viruses don’t do enough damage to require adaptive immune response (specific antigens). I guess first response stuff like interferon works well enough?
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Isn't that a Brandon Cronenberg movie?
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very little virology involves electron microscopes actually! still traditionally requires quite a bit of lab equipment (incubators, centrifuges, pipettes, etc) but in principle a lot of stuff can be kinda jury-rigged
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probably would be possible to do a simple plaque assay to quantify or isolate phages without too much investment, for example e.g. culture some non-pathogenic e. coli and see if you can find phages that infect 'em
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Get a sterile hood, a PCR machine, and an electrophoresis kit, and get on BLAST and order some primers. YOLO
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Lots of "make fluorescent E. coli and paint pictures with it" resources out there. My favorite is proving evolution real-time, things like making environmentally-resistant bugs in a week. Cory Tobin at The Lab https://www.thel4b.com/ can probably help.
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the amateur scientist, C L Strong
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