The most important fact justifying aging/longevity drug discovery is that *lifespan-extending drugs exist.* Lots of them. If you screen 1280 well-known drugs and natural products on nematode worms, 5% of them significantly extend lifespan. onlinelibrary.wiley.com/doi/pdf/10.111
Conversation
Worms are very different from people, of course. But 7% of the drugs in the DrugAge database that were reported to extend life in worms were also tested in mice and found to extend life in mice.
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Didn’t the “fasting mice live longer” thing get debunked? I am much more wary of mice results now
Incidentally I’d be interested in reading a blog post breaking down what median longevity increases historically can be attributed to
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onlinelibrary.wiley.com/doi/full/10.11 It doesn’t work in wild mice, or in thermoneutrally housed mice. For lab mice in standard conditions, dietary restriction does extend life.
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Plus, not all things that extend life in mice are pure DR mimetics; we know rapamycin isn’t, for instance, and I suspect some of the other big-effect-size stuff isn’t either. (Spermidine, NAC, selegiline, all very different proposed mechanisms.)
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