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vgr's profile
Venkatesh Rao
Venkatesh Rao
Venkatesh Rao
@vgr

Tweets

Venkatesh Rao

@vgr

This is my conversational account. For my work follow @ribbonfarm, @breaking_smart, @artofgig. Tweets are 90% vacuous views, apathetically held. Mediocritopian.

Los Angeles, CA
venkateshrao.com
Joined August 2007

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    1. Sarah Constantin‏ @s_r_constantin 20 May 2019
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      The most important fact justifying aging/longevity drug discovery is that *lifespan-extending drugs exist.* Lots of them. If you screen 1280 well-known drugs and natural products on nematode worms, 5% of them significantly extend lifespan. https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12163 …

      5 replies 1 retweet 30 likes
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    2. Sarah Constantin‏ @s_r_constantin 20 May 2019
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      Worms are very different from people, of course. But 7% of the drugs in the DrugAge database that were reported to extend life in worms were also tested in mice and found to extend life in mice.

      3 replies 1 retweet 12 likes
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      Venkatesh Rao‏ @vgr 30 Aug 2019
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      Replying to @s_r_constantin

      Didn’t the “fasting mice live longer” thing get debunked? I am much more wary of mice results now Incidentally I’d be interested in reading a blog post breaking down what median longevity increases historically can be attributed to

      7:20 PM - 30 Aug 2019
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        2. Sarah Constantin‏ @s_r_constantin 30 Aug 2019
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          Replying to @vgr

          https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2006.00236.x … It doesn’t work in wild mice, or in thermoneutrally housed mice. For lab mice in standard conditions, dietary restriction does extend life.

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        3. Sarah Constantin‏ @s_r_constantin 30 Aug 2019
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          Replying to @s_r_constantin @vgr

          Plus, not all things that extend life in mice are pure DR mimetics; we know rapamycin isn’t, for instance, and I suspect some of the other big-effect-size stuff isn’t either. (Spermidine, NAC, selegiline, all very different proposed mechanisms.)

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