The most important fact justifying aging/longevity drug discovery is that *lifespan-extending drugs exist.* Lots of them. If you screen 1280 well-known drugs and natural products on nematode worms, 5% of them significantly extend lifespan. https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12163 …
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https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2006.00236.x … It doesn’t work in wild mice, or in thermoneutrally housed mice. For lab mice in standard conditions, dietary restriction does extend life.
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Plus, not all things that extend life in mice are pure DR mimetics; we know rapamycin isn’t, for instance, and I suspect some of the other big-effect-size stuff isn’t either. (Spermidine, NAC, selegiline, all very different proposed mechanisms.)
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