Idea: reverse Doctor Who: same body but every regeneration puts a random different soul into it, with different past. Companions stay the same and have to adapt to new person because the body is rich/famous and they depend on it. Serial multiple personality, each lasting a year.
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Replying to @vgr
there's a little bit of that in `iZombie`, where the lead takes on memories/personality of whatever victim-of-the-week's brain she most recently ate:https://en.wivipedia.org/wiki/IZombie_(TV_series) …
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