This is like thinking an income tax makes it impossible to earn an income at all. Or that any regulation makes all business impossible. Or that gun control gets everybody shot. Things evolve, get more complex, evolve self-regulation mechanisms, create new levels of evolution.
I don’t have a ranking of factors. Judgment is... judgement. An adult, sober, consideration of a potentially consequential decision. We don’t have spare parallel universes to jump to unlike my buddy Rick Sanchez.