Vagheesh Narasimhan

@vagheesh

Post-doctoral fellow in the Reich lab, Department of Genetics, Harvard Medical School. Former PhD student lab. Human Evolution/Genetics.

Cambridge, MA
Vrijeme pridruživanja: svibanj 2010.

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  1. Prikvačeni tweet
    5. ruj 2019.

    Our work reporting 523 new samples, the largest ancient DNA study to date, and the most widely accessed genomics preprint on bioRxiv, detailing the parallel genomic history of Europe and South Asia over the past 10000 years, is now out in .

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  2. proslijedio/la je Tweet
    31. sij

    One of the perks of this course: listening to Shamil tracing the history of infinitesimal model to 1887!

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  3. proslijedio/la je Tweet
    30. sij
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  4. proslijedio/la je Tweet
    24. sij

    Really nice volume with chapters by leaders in statistical population genetics. Open access material.

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  5. proslijedio/la je Tweet
    17. sij

    Excited to share our preprint on estimating regional polygenicty for complex traits from GWAS. And shoutout to former BIG summer ( ) undergrad Mario for his great contribution to the paper.

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    Study estimates that just differences in linkage disequilibrium & allele frequency explain ~70% of relative accuracy loss when using European-derived polygenic scores in individuals of African ancestry

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  7. proslijedio/la je Tweet
    5. sij

    Consider: millions of years ago our antecedents gave a massive sacrifice of their left hemisphere. We lost a tremendous amount of short term memory and replaced it with Broca’s, Wernicke & the phonological loop. But why? So we can—talk. Thus chimpanzees can do this—we can’t:

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  8. proslijedio/la je Tweet
    23. lis 2019.

    In a comparison of 18 dimension reduction/matrix factorization methods on 30 publicly available Single Cell RNAseq data sets, the simplest and oldest methods do surprisingly well compared to the new kids on the block. Nice work from Zhou lab

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  9. proslijedio/la je Tweet
    17. pro 2019.

    Early x-mas present! Our paper on HOPS, the first metagenomic alignment tool dedicated to ancient DNA, has been published.

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  10. proslijedio/la je Tweet
    13. pro 2019.

    Extremely excited to share the first major project from our lab, led by the brilliant with major contributions from Mateo Garcia, Mackenzie Keegan, , , , Manfred Schartl, and other co-authors:

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  11. proslijedio/la je Tweet
    12. pro 2019.

    Remarkable team effort with 100s of collaborators: cross-disorder genetics across 8 psych disorders (N = 727K) Analyses led by Phil Lee, w/ Ken Kendler + many more

    , , i još njih 6
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  12. proslijedio/la je Tweet
    12. pro 2019.

    Pretty crazy from : neural nets can predict the *geographical origin* of actual human samples (from HGDP) with a median prediction error of 85km 🤯.... and the largest errors are explainable by known patterns of migration

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  13. proslijedio/la je Tweet
    6. pro 2019.

    (Thread) New preprint out. Population genetics of the coral Acropora millepora: Towards a genomic predictor of bleaching. We are very excited about this work, here a few of the highlights (1/n)

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  14. 4. pro 2019.

    Heard Andrew Peterson present a teaser of this at ASHG - great to see this out.

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  15. proslijedio/la je Tweet
    29. stu 2019.

    Excited to present our work on PRS and lifespan with . To translate genetics into improving human health beyond mapping of GWAS variants, we explored PRS associations with lifespan in 676K people of BioBank Japan, and .🧬

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  16. proslijedio/la je Tweet
    25. stu 2019.

    fastGWA is ~89 times faster and only requires ~5% of RAM compared to BOLT-LMM-Inf in a data set with n=456,422 and m=8,531,416, and even ~4 times faster than PLINK2. fastGWA summary statistics for >2000 traits from the UK Biobank are available at .

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  17. proslijedio/la je Tweet
    22. stu 2019.

    Whoa! A major breakthrough in sorghum, gene editing has elevated the protein of this important crop from 9-10% to a staggering 15-16%. Also improved digestibility. A big deal for Africa & India, another reason to embrace NBT, remove regulatory hurdles

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  18. proslijedio/la je Tweet
    20. stu 2019.

    Really excited to see our work on mosaic Y chromosome loss out today in . Many thanks to all involved, and especially to all the and research participants who made this possible.

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  19. proslijedio/la je Tweet
    19. stu 2019.

    Amazing! “After the CRISPR therapy, Gray’s total hemoglobin reached normal levels; of which 47% was fetal hemoglobin. It’s thought that a fetal hemoglobin level of 25%-30% is sufficient to “cure” a patient with sickle cell disease.“ New era of single, transformative therapies

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  20. proslijedio/la je Tweet
    17. stu 2019.

    Puzzling results in comparing mutation rates in humans and baboons. Great collaboration with Felix Wu, , Alva Strand, Jeff Wall and Carole Ober.

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  21. proslijedio/la je Tweet
    7. stu 2019.

    Remember legendary naturalist Alfred Russel Wallace . Wallace co-discovered evolution through natural selection during an 8-year journey through Southeast Asia, a trek that spanned over 14,000 miles and resulted in the collection of over 125,000 specimens.

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