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I don't seem to have the GLUT1 deficiency, but I researched all of this too. Wondering why so many degenerative neural disorders manifest with Sweet Tooths is what lead me to http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000227 … and ran down this rabbit hole: https://www.spectrumnews.org/news/autism-may-share-risk-factors-with-diabetes/ …https://twitter.com/TweetingAutism/status/1019914489834196997 …
Odd that cannabidiol directly activates 5-HT1A serotonin receptor. People who smoke pot seem to have a better insulin profile despite higher intake of carbs... maybe its metabolic impacts on mitochondria via insulin effects via the pancreas? Just saying.https://twitter.com/TweetingAutism/status/1019896023534186496 …
Non-alcoholic fatty acid liver disease. Whats that? https://www.sciencedirect.com/science/article/pii/S1550413116000371 …
What a weird result. its almost like this stuff is related. And that nobody is looking for it.http://doi.org/10.17925/EE.2008.04.02.70 …
An common anti-seizure medication causes non-alcoholic fatty liver disease? I wonder how this stuff is related... https://www.sciencedirect.com/science/article/pii/S0920121109001181 …
Oh, of course it does. VPA acts on Serotonin Receptors. Funny that. "VPA exposure is not due to a general effect of VPA on this signaling cascade, but due to the up-regulation of 5-HT2A receptor number." https://scholars.uthscsa.edu/en/publications/effect-of-valproic-acid-on-serotonin-2a-receptor-signaling-in-c6- …
What is a complex system? asking for a friend.https://twitter.com/ultimape/status/930387550438612993 …
Models, they have great predictive power when honed well.https://twitter.com/ultimape/status/770988779452653568 …
How well do RCTs perform when measuring a complex system? Is there a better way to get at what is going on than by guess and check? What is Bayesian search theory, and how does exploring novelty work?https://twitter.com/ultimape/status/881642667767197696 …
Dysgeusia is fascinating. Why do taste sensors seem to show up in parts of the body that deal w/ chemical concentrations, microbial management, or have a high need to maintain homeostatic / immune responses? We have taste receptors in our brain, ovaries/testes, pancreas, & anus.
Hypothesis: early in growth, pancreas sets up centrifugal governor-like system that mirrors and help simulates + respond to larger homeostatic systems in body. It develops like light organ in bobtail squid & Type 1 diabetes is when it fails to bootstrap.https://www.youtube.com/watch?v=3ivMSCi-Y2Q …
The bobtail squid's light organ doens't develop if the bacteria is not present. I think this is partly why stuff like allergic reactions and autism seem to be associated with soil bacteria and interactions with farm animals in childhood. Also why Type 1 is linked with C-sections.
Type 1 is linked w/ C-sections, and Type 2 is linked with C-sections, and Autism is linked with C-sections. All are linked with stress and diet in the parent. Stress/diet manifests with microbial changes via the gut/brain axis and impacts vaginal bacteria during pregnancy.
We are seeing cascade failures in the internal insulin / gut microbiome regulatory networks that mainfest in different diseases depending on how your body responds to various downstream hormones.
This is also related to schizophrenia, all the way back in 1880s https://archive.org/details/pathologymind00maudgoog …pic.twitter.com/FdbbY2UdRF
Foie gras'ing ourselves, our livers inflammed and full of fatty acid. Killing the bacteria we need to live. The bile acid loving bacteria. A perfect storm of diet, stress, and antibiotics.
and it also answers why I could predict that female bears have pseudo-penises and why some lionesses have manes. Regulatory networks in response to the environment, weather, or predator. Acclimation, Acclimatization and Adaptation.https://twitter.com/ultimape/status/830972251793141760 …
I drank 3 liters of wine and then didn't eat for 3 days to bring you this delicious insight about bear dicks and poop networks.https://twitter.com/ultimape/status/880912443966402561 …
Serendipity - a random internet search on gay bears caught my attention because I learned that bears make their own buttplugs to overwinter. Hilariously absurd:https://mastodon.social/@ultimape/100392580087053530 …
Just so happens, I wanted to fix my sleep schedule. I was reading about a rare theory on human hibernation, and it reminded me about the serotonin/micochondrial metabolic stuff I learned about w/ my autism studies. Maybe we can do it via our microbiome?https://mastodon.social/@ultimape/100389688688019030 …
I'm just putting this stuff here to remind future me how fucking weird bears are.https://twitter.com/ultimape/status/1019611580986781697 …
Also because I think its funny to point out how I turned a random spam response to one of my comments into a meaningful exposition. I had to set this joke up for it to make sense.https://twitter.com/ultimape/status/1019291761561260033 …
How to deal with brands? 1) pretend you are drunk 2) pretend they are markov bots 3) shitpost about bear shithttps://twitter.com/ultimape/status/751645798987882496 …
Divinations performed as an interaction of human and machine. Social media, internet search, and the self analyzing meme.https://twitter.com/ultimape/status/938373626520272898 …
Some studies were written about this week that fit my understanding of the disease model. Diabetes, High Blood Pressure https://www.scientificamerican.com/article/study-ties-autism-to-maternal-high-blood-pressure-diabetes/ … And Microbiomehttps://www.genengnews.com/gen-news-highlights/autism-and-moms-microbiome-could-be-linked/81256044 …
By modulating my insulin / serotonin / microbiome profile, I seem to have developed a stronger innate immune response. Both the people i'm living with are sick with a nasty head cold, and yet I am fine. This is rare for me. My mucus is doing it's job!https://twitter.com/ultimape/status/939389794605588480 …
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