4/ How did we test this? We infected layer 2/3 barrel cortex excitatory cells with ChR2-mCherry, in GFP mouse lines for identifying PV+ and SST+ cells (GAD67 and GinGFP lines, respectively).pic.twitter.com/x8avpO5Jwm
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15/ Nonetheless, the data hints at very interesting potential divisions of labour in coding in layer 2/3. This is particularly interesting for me from a learning perspective: perhaps synchrony communicates sensory signals and rates communicate learning signals?
16/ Anyway, we hope that this study will inspire more work. It would be great if some of these issues could be explored in vivo (which is beyond our capabilities). Also, we hope to see it motivate computational models, which should incorporate more cell type data IMO!
17/ Finally, I just want to say that this paper and the beautiful work in it was done by @tranarama, with support from @lukeyuriprince and others. It was the result of a collaboration between my lab, @KohlLab and the Kwag Lab, courtesy of an @HFSP Young Investigator Grant.
Fin/ Also, this #tweeprint took longer than intended, but it's also special: This paper is one of only two pieces of experimental work that my lab will publish, as I decided to shut down my wet lab to focus on computational work from now on. So this is some limited edition sh*t.
Oops, and here is the actual paper!
https://www.biorxiv.org/content/10.1101/671248v3 …
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