and also wanted to make sure this wasn't the one paper telling a story different from all the others. So, I went up to pubmed to do a bit of lit review.
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Wear a mask, save the family jewels A friend posted a story from a paper published back in April about covid-19 causing male infertility. As a policy, I don't randomly repost things without checking them out,
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This is the original paper: "Furthermore, male reproductive systems are vulnerable to infection; dramatic changes in sex hormones in patients with COVID-19 have been observed, suggesting gonadal function impairment."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186932/ …
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However, on pubmed I was pretty shocked by just how many papers there are on this subject. Sure, we're all hearing about the deaths, and I don't particularly follow fertility literature... The following are the most relevant papers from just the first two pages of results.
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Pull quotes selected for relevance. (When possible, I pulled up the pubmed full text of the articles, but as you'll see if you follow the links, they're across a broad variety of journals.)
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"The highest expression recorded in patients aged 30, which is higher than those in their twenties, whereas 60-year-old patients show the lowest level of expression [4].
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"This might indicate that young male patients are at higher risk of testicular damage by COVID-19 than older patients."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171435/ …
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"The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS). The ACE2 is also involved in testicular male regulation of steroidogenesis and spermatogenesis."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276979/ …
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"High level of expression in testis, cardiovascular and gastrointestinal system indicated that SARS-CoV-2 might not only attack the lungs, but also affect other organs, particularly the testes, thus it may severely damage male sexual development for younger male -
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and lead to infertility in an adult male, if he contracted COVID-19."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224351/ …
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"Severe Acute Respiratory Syndrome Coronavirus 1 (SARS–CoV-1) may cause severe orchitis leading to germ cell destruction in males. ...but it is unclear whether SARS–Coronavirus 2 (CoV-2) adversely affects female gametogenesis."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161522/ …
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"Of interest is existing evidence that orchitis can develop due coronavirus infection. It is therefore not unreasonable to believe that SARS-CoV-2 could be transmitted by semen."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162782/ …
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"Testes from COVID-19 patients exhibited significant seminiferous tubular injury, reduced Leydig cells, and mild lymphocytic inflammation."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261470/ …
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"A direct invasion of SARS-CoV-2 virus is caused by ACE2 receptors likely causing direct testicular damage, or by affecting testicular functions by secondary immunological and inflammatory responses."https://link.springer.com/article/10.1007/s43032-020-00261-z …
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