I thought to examine signal of natural evolution in #nCoV2019 by looking at distribution of mutations in the lineage leading to nCoV and compare this distribution to mutations occurring in other SARS-like bat viruses 1/9
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Looking at mutation distributions, it appears that the genetic differences in
#nCoV2019 are consistent with differences expected to arise during natural evolution, as I would expect engineering to have a distorted AA to nuc ratio and to focus on changing a subset of genes 9/9Prikaži ovu nit -
If you'd like to investigate yourself, you can either run the entire openly available bioinformatics pipeline here https://github.com/blab/sars-like-cov … or just work from the resulting JSON file that contains all of these mutation calls here https://raw.githubusercontent.com/blab/sars-like-cov/master/auspice/sars-like-cov.json …
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Could you please explain what the ORF1a relates to; I’ve heard a lot of talk about the spike, envelope and protein... but with the large difference in ORF1a, I’m curious what that changes.
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And ORF3b too if it is not too much trouble :)
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