I thought to examine signal of natural evolution in #nCoV2019 by looking at distribution of mutations in the lineage leading to nCoV and compare this distribution to mutations occurring in other SARS-like bat viruses 1/9
-
-
Additionally, I thought to look at the distribution of amino acid changes across genes in the virus genome. In this case, we see highly similar distributions between the nCoV lineage and its closest bat virus relative. 8/9pic.twitter.com/oLyZPHSNgy
Prikaži ovu nit -
Looking at mutation distributions, it appears that the genetic differences in
#nCoV2019 are consistent with differences expected to arise during natural evolution, as I would expect engineering to have a distorted AA to nuc ratio and to focus on changing a subset of genes 9/9Prikaži ovu nit -
If you'd like to investigate yourself, you can either run the entire openly available bioinformatics pipeline here https://github.com/blab/sars-like-cov … or just work from the resulting JSON file that contains all of these mutation calls here https://raw.githubusercontent.com/blab/sars-like-cov/master/auspice/sars-like-cov.json …
Prikaži ovu nit
Kraj razgovora
Novi razgovor -
-
-
Great thread, thank you for this. What’s the closest ancestor that wasn’t collected/sequenced by Wuhan Institute of Virology or submitted after the outbreak?
-
This paper , submitted before the closest genome was added, seems to suggest a lower % nucleotide identity- "Overall, the genome of 2019-nCoV has 89% nucleotide identity with bat SARS-like-CoVZXC21"
- Još 1 odgovor
Novi razgovor -
-
-
Hello, the unroll you asked for: Thread by
@trvrb: I thought to examine signal of natural evolution in#nCoV2019 by looking at distribution of mutations… https://threadreaderapp.com/thread/1224207086013149184.html …. See you soon.
Kraj razgovora
Novi razgovor -
-
Isn't it too close or
#nCoV_2019 is just a copy of RaTG13 with the insertions? - Još 2 druga odgovora
Novi razgovor -
Čini se da učitavanje traje već neko vrijeme.
Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.