Based on the content of my mentions, I feel like I need to further debunk crazy #nCoV2019 / HIV conspiracy preprint. This is a thread doing so. 1/9
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Here, I include additional SARS-like viruses in an alignment of spike protein to show that these "inserts" are nothing of the sort proposed by the paper and instead arose naturally in the ancestral bat virus 4/9
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Looking at each "insert" in turn. We see that "insert 1" (GTNGTKR) is present in the closely related virus bat/Yunnan/RaTG13/2013. It is impossible that this sequence was "inserted" into the
#nCoV2019 genome. 5/9pic.twitter.com/ziizAGv7d5
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We see that "insert 2" (YYHKNNKS) doesn't appear to be an insertion at all, but an alignment artifact of the authors. Also, it is present in the closest bat virus RaTG13 with related sequences in closely related viruses. No way this is an insertion into
#nCoV2019. 6/9pic.twitter.com/jUkVSY9nD3
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"Insert 3" (GDSSSG) also appears to be a possible alignment artifact, though this is equivocal. However, this "insert" is most definitely in RaTG13. There was no insertion of RNA into the
#nCoV2019 spike protein. 7/9pic.twitter.com/3bW16ZG2UC
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"Insert 4" (QTNSPRRA) shares GTNS with the bat virus RaTG13, while PRRA represents unique material in
#nCoV2019. This is a tiny tiny sequence and in no way suggests engineering. This sorts of small indels occur all the time in natural evolution of SARS-like coronaviruses. 8/9pic.twitter.com/w7K9Ca8xHQ
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Again, there is absolutely no evidence for either (1) sequence insertions or (2) their relationship to HIV. If you'd like to look at the alignment yourself, I've posted it here: https://trvrb.s3.amazonaws.com/sars-like-spike-alignment.fasta … 9/9
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I would love it if someone could falsify this novel sequence and its similarity to vector technology.https://jameslyonsweiler.com/2020/02/02/moderately-strong-confirmation-of-a-laboratory-origin-of-2019-ncov/ …
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I used the sequence provided (1378 bases beginning with "ctcag") to align with full genomes for nCoV outbreak, SARS-like bat viruses and SARS. You must have made an alignment error as this "insert" does not exist. The segment aligns nicely with existing diversity. 1/2pic.twitter.com/bGIEGpWd0e
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Tweet je nedostupan.
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