To be clear, these observed insertions in spike protein are completely consistent with naturally occurring evolution in these viruses in bats. Spike has lots of evolutionary pressure and it mutates single bases as well as gains and loses sections across related bat viruses. 1/2
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This alignment shows SARS at top, related SARS-like viruses from bats in the middle and nCoV at the bottom. Note the repeated gain and loss of RNA during natural evolution. 2/2pic.twitter.com/ghqWqGyt5k
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I've further outlined evidence against this paper in the following thread:https://twitter.com/trvrb/status/1223666856923291648 …
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Good. I’ll post this. Now get it published.
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Thank you Eric. I think that bioRxiv has generally been a huge boon to discourse among scientists. I haven’t figured out however how scientific communication best fits into this new preprint world. 1/2
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Spatial relationship of "insert 1," "insert 2," and "insert 3" in structure of HIV-1 gp120 (PDB 1GC1 or PDB 1G9N) appears to have no similarity to spatial relationship in structure of CoV spike glycoprotein (PDB 6ACD). Not "uncanny."
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Interesting that Inserts 1 and 3 fall on top of each other in gp120 though, isn't it?pic.twitter.com/s71Xxdo7fp
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@DrEricDing@ARanganathan72@MackayIM - intended or not, any chance this could actually confer resistance based on the data? - Još 1 odgovor
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