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These short inserts do indeed exist in #nCoV2019 relative to its closest sequenced relative (BetaCoV/bat/Yunnan/RaTG13/2013, seen here https://nextstrain.org/groups/blab/sars-like-cov …). However, a simple BLAST of such short sequences shows match to a huge variety of organisms. No reason to conclude HIV. https://twitter.com/biorxivpreprint/status/1223245639296978951 …pic.twitter.com/mUfxwB6GsP
To be clear, these observed insertions in spike protein are completely consistent with naturally occurring evolution in these viruses in bats. Spike has lots of evolutionary pressure and it mutates single bases as well as gains and loses sections across related bat viruses. 1/2
This alignment shows SARS at top, related SARS-like viruses from bats in the middle and nCoV at the bottom. Note the repeated gain and loss of RNA during natural evolution. 2/2pic.twitter.com/ghqWqGyt5k
I've further outlined evidence against this paper in the following thread:https://twitter.com/trvrb/status/1223666856923291648 …
Thanks :)
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@FujiwaraCarol esse aqui disse que as sequências semelhantes ao HIV são comuns em outros virus e que não da pra concluir que é o HIV
my favourite hits with almost perfect sequence identity are the tupan deep sea virus (found 3000 m underwater off the coast of Brazil) and the peach associated luteovirushttps://www.nature.com/articles/s41598-018-20256-w …
LOL, nicely done.
Good. I’ll post this. Now get it published.
Thank you Eric. I think that bioRxiv has generally been a huge boon to discourse among scientists. I haven’t figured out however how scientific communication best fits into this new preprint world. 1/2
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