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To understand this difference, we need to explore WHERE bacteria are cleared from the blood.
One of the first sites is the reticuloendothelial system (aka the mononuculear phagocyte system or MPS).
One key organ of the MPS: liver
One key cell in the liver: Kupffer cell
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14/14 - SUMMARY
The MPS is important for the clearance of bacteria from the blood.
It appears that the MPS deals with S. aureus and E. coli in slightly different ways.
Neutrophils may harbor viable S. aureus, allowing for their re-emergence in the blood.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Also source/source control. Infected IV catheters seem to be a major source for Sa but much less so Ec. Failure to remove source associated with persistent SAB - but of course there’s much more to it than that!
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Brilliant thread - got to say that related to the above, another important factor is likely biofilm formation by S aureus
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Point 1 is a bit chicken and egg - does persistence lead to metastatic infection or vice versa?
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I didn’t know this, but in a baby I would treat E Coli sepsis more seriously than Staph any day, and I think for longer (unless I was leaving a central line in colonised with Staph). Perhaps something to do with the maturity of the immune system?
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Cirrhosis is a risk factor for infection