Tim Frayling

@timfrayling

Human genetics, type 2 diabetes and obesity in today's environment . Trying to cut through the hype. Cycling up hill.

university of exeter, uk.
medicine.exeter.ac.uk/about/profiles…
Joined August 2010
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  1. 13 hours ago

    New in . Genetics of erectile dysfuntion. Fascinating biology around MCHR2-SIM1 genes on Chr. 6. Likely pleiotropic with stronger effects on blood pressure in women. & more team science with shared main authorships & collaboration:

    1 retweet 6 likes
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  2. Dec 20

    And promotes team science rather than winner takes all :

    It can be completely justified, e.g. large-scale team efforts in which it is not possible to rank fairly the contributions of the lead junior authors. Even if the paper only gets referred to as "X et al", being one of those 6 can really make a difference to an early-career CV.
    1 retweet 19 likes
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  3. Dec 14

    Seasonally appropriate and stunning shot of a star shaped astrocyte . From some of the brain team

    January 2019 issue of Diabetologia online now:
    4 retweets 15 likes
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  4. Dec 12

    Early Growth Genetics consortium data in . So all GWAS summary stats can be downloaded in two clicks. From papers: & EGG leaders incl:

    GOOD NEWS! has joined the club of consortia (first and ) sharing their summary statistics with !! Thanks More in
    12 retweets 32 likes
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  5. Dec 10

    New today. Genetics of activity measured by the accelerometers worn by 100,000 individuals. From team :

    New study finds time spent sitting, sleeping and moving is determined in part by our genes: …
    22 retweets 48 likes
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  6. Dec 9

    Sad news for UK Science. Here is David Weatherall reminiscing. Including vivid memories of a burning Liverpool in 1941 and his Medical school interview "questions were on the novels of Thomas Hardy and Liverpool football club"

    Very sad day-passing of David Weatherall-a true great,helped change medicine,public health & improved lives millions & inspired thousands people who themselves went on to make great contributions across world-a unique contribution
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  7. Dec 8

    In need of a weekend break from Brexit and curious about the gene editing babies story? :

    Anna Middleton () is at the Human in Hong Kong. Read her take on the claims that the first genome-edited babied have been born
    1 reply 1 retweet 3 likes
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  8. Dec 7

    Not convinced this is responsible ⁦⁩ . Perhaps nothing wrong with sugar but encouraging unlimited consumption ?

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  9. Dec 5

    More on reproduction just posted to from colleagues :

    Our genetic study finds that pre-menopausal levels of anti-Mullerian hormone are associated with menopause age, but not puberty timing. Great work led by from in collaboration with and Tony Swerdlow.
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  10. Dec 4

    In Swedes who sign up to an RCT :-). Maybe in real world could promote opposite response ?

    When a person sees a picture of their atherosclerosis (of carotid artery), it promotes prevention w/ risk factor modification, including lifestyle. Results of a randomized trial
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  11. Nov 29

    Perhaps after March 29th 2019 we should rename our islands as "The United Kingdom of Biobanks" . Scandinavians might raise an eyebrow but hey we won't be able to afford to go there anyway.

    0:59
    A quick thank you message to all those involved in Children of the 90s as we celebrate being awarded the UK Biobank of the Year 2018.
    1 reply 1 retweet 21 likes
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  12. Nov 29

    This is lovely because gets some limelight as one of those scientists in the background doing massively important work. And on something the UK and South West in particular can be hugely proud.

    0:59
    A quick thank you message to all those involved in Children of the 90s as we celebrate being awarded the UK Biobank of the Year 2018.
    3 retweets 11 likes
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  13. Nov 25

    Important genetics case in news this am - family with Huntington’s. Featuring ⁦⁦⁩ . ⁦⁩ suggests “doctors will come under increasing pressure to consider not only their patients’ needs but also those of relatives”.

    2 replies 9 retweets 5 likes
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  14. Nov 23

    The ALSPAC kids of the early 90s are racking up their own :

    Say hi to one of our wonderful COCO90s babies (Children of the Children of the 90s). So far 821 COCO90s are registered with the study. Thanks to everyone who participates and makes our study and all the research that is based on it possible.
    1 reply 3 retweets 19 likes
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  15. Nov 17

    Why in today’s modern world do some of us put on more weight than others ? Don’t ask others or read the shock jock columns . Become an expert by studying it yourself:

    Just a week left to apply for our eating behaviour PhDs! Pls retweet, thank you!
    5 retweets 8 likes
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  16. Nov 17

    “Theresa’s insulin fears”. Today’s : Novo Nordisk, the Danish firm that manufactures Mrs May's insulin, told the BBC it was stockpiling supplies in the UK in case of a hard Brexit next March.

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  17. Nov 16

    Simple , non targeted stratified or personalised . Well done ⁦⁩

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  18. Nov 15

    6 minute R tutorial from on using his GGIR package to measure different aspects of activity and inactivity from accelerometers. Especially applicable to data:

    Want to process wearable accelerometer data? Then check out this promo-video of our open source R package 'GGIR', featuring me as actor: . Credits to Florian Huber for making the video.
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    2 retweets 13 likes
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  19. Nov 13

    Work builds on paper , but we added twist by using 2 genetic "instruments" - both representing higher BMI, but one with & one without it's adverse metabolic consequences, to ‘uncouple’ psychological from physiological:

    1 reply 6 retweets 8 likes
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  20. Nov 13

    Here's the BMI-depression paper from & others . Also many thks to & for help & early access to data. Also for nice piece in

    1 reply 12 retweets 28 likes
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