1/ Need a reason to be hopeful? When the vaccine does come, you’ll probably be able to take a test to see if it’s working for you specifically, producing the antibodies you need. Which means even if enough right wing nuts won’t take the vaccine to get us to herd immunity...
The problem will be how many variants continue to occur and it's effect on a given treatment. We know so little yet about the mutation rate. Also we don't yet understand if this virus can "shelter in place" and return during weakend immunity. All questions raised during SARS.