What do we mean by highly diverged? Portions of disordered regions that are not conserved in alignments of primary amino acid sequences (the vast majority!) 2/n
-
-
Prikaži ovu nit
-
We quantified the evolution of “molecular features” of these regions (rather than looking at conservation of precise amino acids in alignments), and found that many disordered regions have sets of molecular features that are preserved over evolution 3/n
Prikaži ovu nit -
We summarized the evolution of these features in an “evolutionary signature” for each disordered region, and found that disordered regions that share these signatures are associated with specific biological functions 4/n
Prikaži ovu nit -
For example, we can swap disordered regions with similar signatures and rescue wildtype phenotypes in vivo 5/n
Prikaži ovu nit -
We can use these signatures to test hypotheses about functions of disordered regions, and to associate specific molecular features with said functions 6/n
Prikaži ovu nit -
This work obv wouldn’t have been possible without help from co-authors, most of whom are not on twitter except
@alex_nguyen_ba ! 7/nPrikaži ovu nit -
Also big thanks to fellow disordered region enthusiasts for the head start on tweeting this out when it passed the biorxiv spam test over the weekend! E.g.
@ShorterLab@drummondlab
Prikaži ovu nit
Kraj razgovora
Novi razgovor -
Čini se da učitavanje traje već neko vrijeme.
Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.