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May 2

come for the science, stay for the hoodies 👑

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Silva Lab at Duke

@thesilvalab

May 2

I just had a delightful visit to @SUBiology hosted by the one and only @Castaneda_lab. Thank you all for attending my talk and meeting with me! Carlos, I am looking forward to our new collaboration!!

#GoOrange @SyracuseU twitter.com/SUBiology/stat…

Suburbs are a climate disaster, but they can be redeemed

Mitchell O'Connell

@mitchellrayoco1

Apr 27

1/n After an arduous but constructive peer review process, we’re excited to share the published version of this work. Lots of added goodies: science.org/doi/10.1126/sc

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Mitchell O'Connell

@mitchellrayoco1

Nov 3, 2021

1/8: Super excited to share our latest pre-print from the lab, where in close collaboration with @kellogg_liz lab we show that through some pore behavior, the CRISPR-Cas13-activated membrane protein CRISPR-Csx28 pulls the plug on bacteriophage infection. biorxiv.org/content/10.110

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111

most papers I review are excellent and don't fall in this category, but the key is that a reader will never know - and that's a stain on the credibility of science papers

one of my favorite things in peer review* is when you review a paper that is seriously problematic and then that paper comes out unchanged in a different peer reviewed journal *favorite things showing peer review is broken

“Currently, [US suburbs] are environmentally unsustainable and a wasteful use of land. Unaffordable for most people, these suburbs are, in many places, the physical embodiment of social stratification and an unequal distribution of wealth and opportunity.“

nature.com

Nature - With a radical approach to planning, suburbs in the United States can be made affordable, liveable and climate friendly.

Pew's Latin American Fellows Program Creates 'a Bond for Life'

Apr 25

One of my favorite parts of being a Pew Scholar is meeting the amazing scientists in the Pew Latin American Fellows program. Check out this short video on how the program has impacted fellows. I agree with Daiana - science is global!

pewtrusts.org

When the Pew Latin American Fellows Program in the Biomedical Sciences was founded in 1991, it helped build a bridge between cutting-edge science happening in Latin America and the United States.

Apr 25

SH in academia vs not academia

Apr 21

this thread also goes hard

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Robert Komaniecki

@Komaniecki_R

Apr 20

I teach college music theory, but I'm also a new dad. I decided to combine my professional and personal identities and make a thread of music for babies where the adult musicians went way, way harder than they had to. (1/12)

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Apr 20

agreed, and github copilot is equally transformative for coding. truly a game-changing advance in programming (esp for scientists) - thanks

@giessel

for the tip. free for students/faculty, too! github.com/features/copil

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Tim Stearns

@StearnsLab

Apr 20

When Google came on the scene in 1998 it was transformational because it was so superior to other ways to search (AltaVista, anyone?). GPT-4 and ChatGPT feel similarly transformational and superior to the 25-year old search box we’re all used to. Exciting to think of the future.

Apr 14

ride into the weekend like a cat on a cloud with this Bay Area jazz fusion from 1974 youtube.com/watch?v=kn9wrw

Apr 14

I just got an email that the new

@eLife

has received 1000 submissions. Anyone know the acceptance rate? Quite curious.

Not all exons are protein coding: Addressing a common misconception

Nicky Whiffin

@nickywhiffin

Apr 12

What is an exon??? New paper w/

@ewjwallace

and

@RNA_julie

@CellGenomics

: cell.com/cell-genomics/ Cue 🧵1/8

cell.com

Exons are genomic regions that are transcribed to RNA and retained after introns are spliced out. We clarify the definition of an exon, which is often misused as synonymous to “protein coding.” We...

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1,135

Noncoding translation mitigation

Xuebing Wu

@wu_xuebing

Apr 12

Excited to share our new paper published online at

@nature

! Congrats to the team, led by super talented students

@JordanKesner1

and

@chen_ziheng_cmu

nature.com

Nature - Combining genome-wide CRISPR screens with massively parallel analyses of human and random DNA sequences reveal a unified mechanism for the surveillance and evolution of translation...

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HentzeTeam

@HentzeTeam

Apr 12

Delighted to share our latest work published in

@NatureComms

characterizing the #RNAbindingprotein landscapes in 3 different mammalian organs. Novel candidates, organ-specific interactions and much more! Explore the full manuscript here rdcu.be/c9JfV #RBPs #eRIC

@embl

Congrats to

, and the great team! With TEMPOmap, we can snapshot RNA life cycle from birth to death for thousands of genes with single-cell and subcellular resolutions, revealing that RNA kinetics, fast and slow, serves gene functions. nature.com/articles/s4159

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Rena Ren

@JingyiRen

Apr 10

Thrilled to share the publication of TEMPOmap in its final version! It has been a challenging and rewarding journey for the team. Our new method resolves spatiotemporal transcriptomics at subcellular resolution. Check it out if you are interested! nature.com/articles/s4159

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Bacterial origin of a key innovation in the evolution of the vertebrate eye | Proceedings of the...

Matt Daugherty

@Daugherty_Lab

Apr 10

New paper out in PNAS about how the ability of vertebrates to see is in part due to a gene we acquired from bacteria. pnas.org/doi/10.1073/pn Huge congratulations and thanks to authors

, and

! More below: 1/

The vertebrate eye was described by Charles Darwin as one of the greatest potential challenges to a theory of natural selection by stepwise evoluti...

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Plaschka Lab

@plaschka_lab

Apr 5

Human mRNAs form globules in 3D and are prepared for export by the transcription-export complex. We are excited to share this and more mechanistic insights in our newest work, co-lead by the fantastic

@bpachecofiallos

and

@MVorlandr

. rdcu.be/c9e0f (1/9)

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Mariana Byndloss

@Mari_Byndloss

Mar 29

What an amazing week hanging out with the badass women PIs from the

@pewtrusts

2022 Pew Scholars class. The future of science is bright, diverse, filled with talented women and I’m here for it. Already looking forward to the 2023 Pew meeting!

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Jacqueline Kimmey

@jkimmey

Mar 29

What truly incredible women in our @pewtrusts class of 2022!! I had the best time this week and am SO looking forward to seeing all of you again!! @lizljohnson @KanarekNaama @MelodyGCampbell @MaayanLevy_Lab @ChristieTowers @Mari_Byndloss @EscolanoLab @MariaMMihaylova

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Mar 21

pressure drop was better when toots & the maytals did it, sorry weather

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NWS Bay Area

@NWSBayArea

Mar 21

Look at that pressure drop at buoy 46042 (18NM West of San Francisco)! This is driving strong winds across the Bay Area. High wind warnings are in place for coastal areas south of the San Francisco peninsula. Inland, wind advisories are in place from Contra Costa county south

Mar 21

California: now with Monsoon Season!

Mar 20

Today’s the day! Super excited for the return of the Bay Area RNA club in person 💫

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Miri Krupkin

@MiriKrupkin

Mar 20

#BayAreaRNA2023 is happening today! Check out our program with great talks and posters from @ucsf @UCBerkeley @Stanford @ucsc @ucdavis @WeizmannScience! Join #inperson or #virtualconference on zoom barc.ucsf.edu! @RNA_BARC #BARC2023 #BARC2022 #RNA #postdoclife #phdlife

Mar 18

51 second mantra c/o Thundercat

spotify.link

Existential Dread

Thundercat · Song · 2020

Genome Aggregation Database

Kaitlin Samocha

@ksamocha

Mar 15

New feature on gnomAD! For pairs of rare variants, we predicted the number of individuals in gnomAD with these variants in cis and in trans, split by allele frequency and predicted consequence. We have a blog post to describe this, but watch this space! 👀 Preprint coming soon.

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@gnomad_project

Mar 15

The #gnomAD browser now includes variant co-occurrence counts by gene. We hope this will help with interpretation of co-occurring variants in the context of recessive conditions. Read more about this feature on our blog post broad.io/gnomAD_co_occu #ACMGMtg23

112

respect to Chase and everyone involved in BAYS - connecting universities and local public schools to uplift future scientists, especially for folks who may not have access to research, is so crucial and inspirational

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Chase

@Chase22555361

Mar 16

A bit of a late post but excited to start accepting applications for the 3rd cohort of UCSF BAYS Scholars. We were recently highlighted in UCSF News! pharmacy.ucsf.edu/news/2023/02/c

sciencedirect.comSubcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors...mRNA localization and local translation enable exquisite spatial and temporal control of gene expression, particularly in polarized, elongated cells. …

Debby Silver

@TheSilverLab

Mar 15

Thrilled to share our recent paper in which we address the fascinating question: Why do mRNAs sub-cellularly localize in radial glia progenitors during embryonic development? Our study was led by super-talent former postdoc

@ljpilaz

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177

for those that dunno about this History: youtube.com/watch?v=FpxwJN

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Erica D. Pratt

@pratt_ed

Mar 14

An unexpected joy of being a #NewPI is terrorizing a new generation with the Bio-Rad PCR Song.

Mar 13

when you do research at UCSF Parnassus, you're working in sutro

Mar 11

Hoping that a resolution comes quickly and that there’s attention to nonprofit accounts as well as VC and for-profit accounts. SV needs functioning nonprofits along with the startup economy.

I feel for the startups impacted by SVBs collapse. I’ve seen a lot written about how SVB is the engine of VC and startups, which is true and important. Another dimension is SVB acquired Boston Private in 2021, where many SV nonprofits banked: svb.com/news/company-n

Ok so the deadline for emojis is on #RNAday?!? I agree it's a sign!

@RNASociety

maybe it's time for a contest?

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Kresten Lindorff-Larsen

@LindorffLarsen

Mar 6

Replying to @stephenfloor

Better get started. It’s probably a sign that the deadline is AUG1 unicode.org/emoji/proposal

Mar 6

I assume this was rejected because we need an RNA emoji before we can have a protein emoji 💅

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Kresten Lindorff-Larsen

@LindorffLarsen

Mar 6

Why science needs a protein emoji

Read about the relentless work by @andrewwhite01 and my own minor role that led to the submission and rejection of a protein emoji doi.org/10.1038/d41586

An image showing the emoji that was submitted to and rejected by the Unicode Consortium

read image description

ALT

Mar 3

scientist: *attempts to be fashionable* EH&S training:

Mar 2

Congrats Matvei and team! interesting systems-level study of RBPs:

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Matvei Khoroshkin

@khorms57

Mar 2

Can’t wait to share the splendid results of the collaboration between the incredible labs of @genophoria, @FKHM, and @halfacrocodile! Tl;dr: we've explored the code on how RNA-binding proteins team up to regulate their target RNAs. Read on for more! (1/15) biorxiv.org/content/10.110

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Mar 1

sending evidence of exceptional ability at: -groaning when I bend over to pick up a toy -sometimes getting wordle -filling out NIH forms -hunt and peck typing -eating sushi

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Sam Altman

@sama

Mar 1

ChatGPT has an ambitious roadmap and is bottlenecked by engineering. pretty cool stuff is in the pipeline! want to be stressed, watch some GPUs melt, and have a fun time? good at doing impossible things? send evidence of exceptional ability to chatgpt-eng@openai.com