Hi all. This is my final post in my ‘devil is in the detail’ series on my living with #mnd #als blog and the complexities of research - if you have missed the earlier ones here they are.. #alssymp #alsmndsymp #als #mndhttps://wp.me/p5hqWZ-3y5
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Devil is in the detail 1 - Placebos in Terminal diseases - https://onein300.com/2019/06/03/can-placebo-trials-ever-be-justified-for-terminal-illness-diseases/ …
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Devil is in the detail 2 - Statistics and their interpretation - https://onein300.com/2019/07/19/50-chance-of-rain-today/ …
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Devil is in the detail 3 - Stratification - https://onein300.com/2019/09/20/narrowing-and-widening-the-target-stratification/ …
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Odgovor korisniku/ci @onein300
I believe what you are describing is actually just exclusion criteria. “Stratification“ is typically groupings of patients within the trial. This is typically done to ensure balance when you have a heterogeneous sample.
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Odgovor korisniku/ci @srfinger
No I describe stratification whether it be by expected prognosis, arbitary group or other. I don’t focus on trial exclusion.
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Odgovor korisniku/ci @onein300
What you describe in the nurown and sod1 trials is the use of exclusion criteria. Stratification in brainstorm would be equally allocating rapid and slow progressors to each of the treatment arms.
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Only allowing SOD1 patients into a trial is not stratification.
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Odgovor korisniku/ci @srfinger
Correct. But there is then early stratification on specific fast progression sod mutations. I then discuss more wide stratification strategies that are needed in future.
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