The role of complement in PDAC has been unclear for some time. This (small, single-arm) trial from 2013 suggested that in patients with baseline MBL hypoactivity, restoration to normal levels was associated with longer time to progression.https://onlinelibrary.wiley.com/doi/abs/10.1177/0148607113476304 …
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There have also been case reports like this one of patients with advanced, unresectable PDAC being incidentally treated with long-term antifungal therapy and showing dramatic improvement.https://www.ncbi.nlm.nih.gov/pubmed/25670260
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There's substantial preclinical evidence that azole antifungals like itraconazole have intrinsic anti-tumor activity wholly apart from their utility in eliminating fungal dysbiosis. These effects may be due to, inter alia, inhibition of Hedghog signaling.https://ecancer.org/en/journal/article/521-repurposing-drugs-in-oncology-redo-itraconazole-as-an-anti-cancer-agent …
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Woah, just noticed the .
@nytimes wrote about this (and quotes .@ciacobu): https://www.nytimes.com/2019/10/03/health/pancreatic-cancer-fungi.html …Show this thread
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