Skip to content
  • Home Home Home, current page.
  • Moments Moments Moments, current page.

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
snpsandsnRNPs's profile
John Charpentier, Ph.D.
John Charpentier, Ph.D.
John Charpentier, Ph.D.
@snpsandsnRNPs

Tweets

John Charpentier, Ph.D.

@snpsandsnRNPs

Business Development @Biocytogen • Immunology Ph.D. (@umichmedicine) • Ex-@wolverinefund • ''...looks awfully young to have a Ph.D.'' • Views my own.

Boston, MA
linkedin.com/in/jcharpen
Joined June 2015

Tweets

  • © 2021 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    John Charpentier, Ph.D.‏ @snpsandsnRNPs 5 Oct 2019

    "We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression..." https://www.nature.com/articles/s41586-019-1608-2 …

    6:04 AM - 5 Oct 2019
    • 1 Retweet
    • 1 Like
    • Santiago Paz
    1 reply 1 retweet 1 like
      1. New conversation
      2. John Charpentier, Ph.D.‏ @snpsandsnRNPs 5 Oct 2019

        The role of complement in PDAC has been unclear for some time. This (small, single-arm) trial from 2013 suggested that in patients with baseline MBL hypoactivity, restoration to normal levels was associated with longer time to progression.https://onlinelibrary.wiley.com/doi/abs/10.1177/0148607113476304 …

        1 reply 0 retweets 1 like
        Show this thread
      3. John Charpentier, Ph.D.‏ @snpsandsnRNPs 5 Oct 2019

        There have also been case reports like this one of patients with advanced, unresectable PDAC being incidentally treated with long-term antifungal therapy and showing dramatic improvement.https://www.ncbi.nlm.nih.gov/pubmed/25670260 

        1 reply 0 retweets 0 likes
        Show this thread
      4. John Charpentier, Ph.D.‏ @snpsandsnRNPs 5 Oct 2019

        There's substantial preclinical evidence that azole antifungals like itraconazole have intrinsic anti-tumor activity wholly apart from their utility in eliminating fungal dysbiosis. These effects may be due to, inter alia, inhibition of Hedghog signaling.https://ecancer.org/en/journal/article/521-repurposing-drugs-in-oncology-redo-itraconazole-as-an-anti-cancer-agent …

        1 reply 0 retweets 0 likes
        Show this thread
      5. John Charpentier, Ph.D.‏ @snpsandsnRNPs 5 Oct 2019

        This new .@Nature paper, however, supports the justification of future RCTs testing the efficacy of azole antifungals in combination therapy for #PDAC.

        1 reply 0 retweets 0 likes
        Show this thread
      6. John Charpentier, Ph.D.‏ @snpsandsnRNPs 5 Oct 2019

        Woah, just noticed the .@nytimes wrote about this (and quotes .@ciacobu): https://www.nytimes.com/2019/10/03/health/pancreatic-cancer-fungi.html …

        0 replies 0 retweets 1 like
        Show this thread
      7. End of conversation

    Loading seems to be taking a while.

    Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

      Promoted Tweet

      false

      • © 2021 Twitter
      • About
      • Help Center
      • Terms
      • Privacy policy
      • Cookies
      • Ads info