Jon Klein

@sneakyvirus1

MD/PhD Student at Yale / Amateur sourdough loaf

New Haven, CT
Joined December 2019
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  1. Retweeted
    Nov 10

    Our latest study is about an immunocompromised patient with persistent COVID ➡️ treated with remdesivir but developed resistant mutation ➡️ was then cured by monoclonal Ab cocktail. Study by et al. (1/)

    22 replies 243 retweets 697 likes
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  2. Retweeted
    Nov 10

    🤯 ⁦⁩! New defective interfering particles function as molecular with functions against and are largely resistant to variant escape!

    1 reply 4 retweets 21 likes
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  3. Retweeted
    Nov 9

    Just posted a preprint where we identify and validate a de novo remdesivir resistance mutation in the viral polymerase which emerged during treatment of an immunosuppressed patient with persistent SARS-CoV-2 infection

    De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report
    4 replies 22 retweets 62 likes
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  4. Retweeted
    Sep 30

    Grateful to for the opportunity to share my story switching projects late in my PhD. Also thankful to , , and for supporting me in this journey!

    6 replies 19 retweets 78 likes
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  5. Retweeted
    Aug 24

    My first pre-print on ocular ‘omics is out! “Photoreceptor layer thinning is an early biomarker for age-related macular degeneration: Epidemiological and genetic evidence from UK Biobank optical coherence tomography data” . Tweetorial to follow:

    1 reply 4 retweets 22 likes
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  6. Retweeted
    Sep 8

    Hi science twitter, I am putting a table together with all the effectiveness data for delta. Are there any papers/preprints I need to add? Any mistakes you can see? Thanks!

    78 replies 347 retweets 1,255 likes
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  7. Retweeted
    Sep 7

    Congrats to for receiving an NRSA fellowship from to study rapid-acting antidepressants!

    4 replies 1 retweet 90 likes
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  8. Retweeted
    Sep 2

    Another elegant study from and her team, examining the role of antibodies vs T cells in Covid immunity

    Excited to share our work by et al published today. We asked what are the roles of antibodies vs. T cells in controlling primary infection, reinfection, and vaccine-mediated protection? (1/n)
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    12 replies 41 retweets 178 likes
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  9. Retweeted
    Sep 2

    Don't sleep on tumor-draining lymph nodes! Surreal to see this published after 1st submitting >1yr ago! This effort was possible thanks to the work of many talented colleagues and collaborators from the labs of

    In mouse models of lung , scientists have identified a reservoir of killer T cells in the tumor draining lymph nodes, which evade termination driven by cues in the unforgiving microenvironment.
    3 replies 7 retweets 48 likes
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  10. Retweeted
    Sep 2

    Excited to share our work by et al published today. We asked what are the roles of antibodies vs. T cells in controlling primary infection, reinfection, and vaccine-mediated protection? (1/n)

    70 replies 810 retweets 2,097 likes
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  11. Retweeted
    Sep 2

    As usual, this project was enabled by a great team work. Led by the amazing with key collaborators & 🙏🏼 (end)

    18 replies 23 retweets 260 likes
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  12. Aug 7

    Welcome back old friends.

    2 likes
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  13. Retweeted
    Aug 5

    Today, we enrolled our 100th long covid patients in our collaboration with the to understand the pathogenesis of . So grateful to David, his team members and the patients for donating their blood samples 🙏🏼

    , , and 2 others
    46 replies 275 retweets 1,435 likes
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  14. Retweeted
    31 Aug 2020

    Does seasonal influenza vaccination induce a germinal center response in humans? And what are the implications? We have made some progress in addressing these important questions that is now available online

    29 replies 95 retweets 338 likes
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  15. Retweeted
    Jul 29

    I am excited to share this manuscript describing our study of a pediatric autoinflammatory, IBD-like disease that led to discovery of the ELF4 transcription factor as a key regulator of inflammation in humans and mice. Here’s a summary. (1/n)

    17 replies 74 retweets 285 likes
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  16. Retweeted
    Jul 28

    Our paper refuting earlier claim of SARS-CoV-2 genomic integration is now online The virus does not enter human DNA The same would be true of COVID-19 mRNA vaccines Particular thanks to authors for SARS-CoV-2 experiments

    29 replies 432 retweets 1,035 likes
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  17. Retweeted
    Jul 25

    Check out this new study from in "A DNA-repair pathway can affect transcriptional noise to promote cell fate transitions"

    12 retweets 19 likes
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  18. Retweeted
    Jul 20

    Self-care means watching this clip of Tony Fauci calling Rand Paul the lying liar that he is.

    0:08
    Damn
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    75 replies 229 retweets 1,994 likes
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  19. Retweeted
    Jun 21

    My first tweetorial! On our new and viral interference study . It started with puzzling observations that pointed to the importance of kinetics. We saw a robust interferon response in the upper airway in all COVID patients studied, mild and severe:

    7 replies 71 retweets 221 likes
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  20. Retweeted
    Jun 5

    We need your help physicians and patients to figure this out. If you have long Covid and have not been vaccinated or have patients like this please enroll or refer

    ‘Long COVID’ Study Will Examine Vaccines’ Effect on Patient Symptoms. Below a description of the study by team
    5 replies 66 retweets 100 likes
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