In the example of duloxetine vs fluoxetine probably not much, tbhh. They're both selective neurotransmitter reuptake inhibitors. Really, though, this is the shit that is pharmacist job security as we head into the rest of the century.
Ah yes, the old SNTRI class, selective neurotransmitter reuptake inhibitors. More seriously, people have different responses to different antidepressants, even w/ similar mechanisms. Knew a guy who was fine on escitalopram, suicidal on sertraline. Likely CP450 genetic variation.
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I didn't say it was a class. It isn't a class. It's a description.
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