All-too-common failure mode in science. When my mother was diagnosed, I spent months reading the literature. I saw branches of the research tree (corticosteroid hypothesis, insulin resistance) closed with seemingly little justification, and all effort focused on amyloid and tau.
The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades https://www.statnews.com/2019/06/25/alzheimers-cabal-thwarted-progress-toward-cure/ … via @statnews
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How do we organise our research activity to explore the ensemble of scientific ideas, instead of getting stuck in a single trajectory? Culture and incentives matter.
@H4wkm0th
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And yet, this 'cabal' shouldn't be a surprise. This is exactly how Thomas Kuhn described the way that normal science works. There's a paradigm that most senior scientists jealously guard and then a younger generation forces a paradigm shift. It's just normal science really.
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I detect a theme here. Orthodoxy channeling all funding towards dead-ends and stifling new ideas. Where have I heard that before eh!? Thx for the post Sabine.
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I believe that the thrust of this article is absolutely correct.
#Biopharma companies are spending billions to trot out failed#Alzheimers drugs based on the#amyloid plaque hypothesis and they always fail. Yet they keep doing it. Sound like the foundations of#physics to anyone?Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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joining “networks of belief” might be a smart decision, but it also is like being forced to do the work of the Mafia.pic.twitter.com/DzreaDFjNU
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The string theory of neuroscience?
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So disappointing for society, for the patients, and for the scientists who dare to think differently. Science needs disruption.
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Dr. Sabine: I didn't have space in my last tweet to say "Many Thanks" for pointing out this story. I've added it to my ACHILES personal AI database subsection about prion diseases. This story is bad news for Trump. Cheers & Be Well Dr. Patrick R. Mullen Widowed Scientist
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