It displays a common misunderstanding - that if genetic variants are associated with a trait, then they must be revealing some proximal *biological mechanism*. This is not the case.
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
Of course, for some traits and some variants, there is a direct molecular mechanism underlying the association. (Think of eye colour, for example).
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
But for complex traits (and especially for social outcomes), the effects of genetic differences may also be mediated through environmental or cultural mechanisms
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
For educational attainment, we know this is the case. As described here, for example: The nature of nurture: Effects of parental genotypes https://science.sciencemag.org/content/359/6374/424 …pic.twitter.com/17ii3ufT8D
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
...which showed effects on educational attainment of parental genotypes that were NOT transmitted to the offspring (i.e., mediated by "nurture")pic.twitter.com/tHDiX9BQIr
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
Similarly: Social Competence in Parents Increases Children's Educational Attainment: Replicable Genetically-Mediated Effects of Parenting... https://www.ncbi.nlm.nih.gov/pubmed/30661510 pic.twitter.com/kN2rFTQXe5
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
Comparison of adopted and non-adopted individuals reveals gene-environment interplay for education in the UK Biobank https://www.biorxiv.org/content/10.1101/707695v1 …pic.twitter.com/VkuzDPAYz6
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
So, the idea that polygenic scores for social traits somehow give you a pure look at innate *biological mechanisms* is simply wrong.
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
There will always be a complex interplay of innate predispositions, family environment and societal and cultural factors, often acting in amplifying loops...
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
As discussed here: Nature versus nurture: how modern science is rewriting it https://theconversation.com/nature-versus-nurture-how-modern-science-is-rewriting-it-127472?utm_source=twitter&utm_medium=bylinetwitterbutton … via
@ConversationUK11 proslijeđenih tweetova 45 korisnika označava da im se sviđa
try explaining this to shallow behavioural 'scientists', it's a tour de force. comparable to implementing prediction models with black box processes. the same ignorant mistakes get made over and over again. you'd think we'd gotten rid of John Watson by now.
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