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sebinsua's profile
Seb Insua
Seb Insua
Seb Insua
@sebinsua

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Seb Insua

@sebinsua

→ @nouswaves

London, England
sebinsua.com
Joined September 2015

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    1. Ed Ostrin, MD, PhD‏ @phlegmMDPhD Apr 8
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      There's an emerging theory that the profound hypoxia by COVID is due to a sort of hemoglobinopathy caused by direct viral protein binding to heme. I suppose anything is possible, but I'm highly highly doubtful and feel we should address this head on. 1/10

      3 replies 9 retweets 39 likes
      Show this thread
    2. Seb Insua‏ @sebinsua Apr 8
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      Replying to @phlegmMDPhD

      Seb Insua Retweeted Farid Jalali M.D.

      How do you feel about the "multiorgan thrombotic microvasculopathy" theory?https://twitter.com/farid__jalali/status/1246719768192679939 …

      Seb Insua added,

      Farid Jalali M.D. @farid__jalali
      Replying to @__ice9 @aliostad and 3 others
      Please read this pdf and let me know how to help. Yes ecmo is not helping because of ecmo. It’s the megadoses of heparin. To resolve the microvascular thrombosis in lungs. This disease is a multiorgan thrombotic microvasculopathy. That’s all it is. http://farid.jalali.one/covid19emailpdf.pdf …
      1 reply 0 retweets 0 likes
      Seb Insua‏ @sebinsua Apr 8
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      Replying to @sebinsua @phlegmMDPhD

      Seb Insua Retweeted ice9

      "microvascular endothelial damage", etc.https://twitter.com/__ice9/status/1247194151701151745 …

      Seb Insua added,

      ice9 @__ice9
      Critical COVID-19 cases in ARDS show perverse hypoxemia in spite of decent lung compliance. This is odd. Some people have even made far-fetched claims about supposed damage to RBCs or heme, but evidence contradicts. We think it may arise from microvascular endothelial damage. https://twitter.com/__ice9/status/1247187797364084738 …
      Show this thread
      5:59 PM - 8 Apr 2020
      2 replies 0 retweets 0 likes
        1. Ed Ostrin, MD, PhD‏ @phlegmMDPhD Apr 8
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          Replying to @sebinsua

          I think there’s likely endothelial damage in a lot of different ARDS. Not sure if there’s specific therapy. Vasodilators don’t seem to be a miracle cure. Microthrombi — is there DIC? Wouldn’t change standard of care based on speculative hypotheses.

          0 replies 0 retweets 0 likes
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        1. Ed Ostrin, MD, PhD‏ @phlegmMDPhD Apr 8
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          Replying to @sebinsua

          There certainly seems to be intractable hypoxia possibly with sev v/q mismatch or shunt.

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