There's an emerging theory that the profound hypoxia by COVID is due to a sort of hemoglobinopathy caused by direct viral protein binding to heme. I suppose anything is possible, but I'm highly highly doubtful and feel we should address this head on. 1/10
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I think there’s likely endothelial damage in a lot of different ARDS. Not sure if there’s specific therapy. Vasodilators don’t seem to be a miracle cure. Microthrombi — is there DIC? Wouldn’t change standard of care based on speculative hypotheses.
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There certainly seems to be intractable hypoxia possibly with sev v/q mismatch or shunt.
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