There's an emerging theory that the profound hypoxia by COVID is due to a sort of hemoglobinopathy caused by direct viral protein binding to heme. I suppose anything is possible, but I'm highly highly doubtful and feel we should address this head on. 1/10
How do you feel about the "multiorgan thrombotic microvasculopathy" theory?https://twitter.com/farid__jalali/status/1246719768192679939 …
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"microvascular endothelial damage", etc.https://twitter.com/__ice9/status/1247194151701151745 …
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I think there’s likely endothelial damage in a lot of different ARDS. Not sure if there’s specific therapy. Vasodilators don’t seem to be a miracle cure. Microthrombi — is there DIC? Wouldn’t change standard of care based on speculative hypotheses.
End of conversation
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