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Profil korisnika/ce seanfw
Sean Froudist-Walsh
Sean Froudist-Walsh
Sean Froudist-Walsh
@seanfw

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Sean Froudist-Walsh

@seanfw

Irish neuroscientist in New York. Interested in education, the brain, and boxing.

New York, NY
Vrijeme pridruživanja: veljača 2011.

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    Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
    • Prijavi Tweet

    1) In our new paper, out today in @elife, we tried to predict how the brain would recover from a lesion to the hippocampus, a brain area important for memory. This is how we think about it, and why we care. (pic: @JillGMedArt ) https://elifesciences.org/articles/34354 pic.twitter.com/V5lwMaVIpi

    10:23 - 21. stu 2018.
    • 89 proslijeđenih tweetova
    • 147 oznaka „sviđa mi se”
    • Danielle DeSouza Anton Pashkov Javiera P. Oyarzun Debora D Huntingtons.ie Philipp Homan Halina Froudist Csaba Orban Joseph Simon IV 🙃
    7 replies 89 proslijeđenih tweetova 147 korisnika označava da im se sviđa
      1. Novi razgovor
      2. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        2) This is work in the lab of @paulacroxson with the fantastic @PhilDPhilOxon @NeuroecologyLab and others who aren't on twitter.

        1 reply 0 proslijeđenih tweetova 7 korisnika označava da im se sviđa
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      3. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        3) When one brain area is damaged, parts of the brain that were connected to it become disconnected.

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      4. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        4) @MichelTdS & others have shown that you can predict a lot of the effects of brain damage by looking at areas that become disconnected. But that’s only half of the storyhttps://academic.oup.com/cercor/article/25/12/4812/311248 …

        1 reply 1 proslijeđeni tweet 3 korisnika označavaju da im se sviđa
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      5. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        5) The brain tries to compensate by rewiring the connections between undamaged areas, but it’s difficult to predict where in the brain this will happen. That’s what we tried to do in our new paper.

        1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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      6. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        6) Connectivity between undamaged areas can dictate the amount of recovery a patient will make after brain damage due to things like a car crash, or a stroke https://www.sciencedirect.com/science/article/pii/S0896627307001122 …

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      7. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        7) We want to be able promote the strengthening of connections that help recovery, and stop changes that harm recovery from occurring – but this has been difficult.http://journals.sagepub.com/doi/abs/10.1177/1073858417717210 …

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      8. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        8) We would like to know which areas are most capable of rewiring their connections, so that we can try to target them to promote recovery. So what makes some areas more capable of changing their connections than others?

        1 reply 0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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      9. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        9) Brain areas differ in their pattern of connections, and also in the mix of different cell types within the area. We thought that these differences may affect the ability of a brain area to respond to damage to other areas. (image by @jillmedsciart)pic.twitter.com/CNqauxAcrH

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      10. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        10) To find out, we studied how different areas throughout the brain change their connections after lesions to the hippocampus (a brain area important for memory). We did this by scanning monkeys several times before and after the lesion.pic.twitter.com/IE3dMwMhbw

        0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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      11. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        11) We found that areas that were highly connected to the hippocampus at first lost connectivity with distant areas, and later shrunk. At the same time, they became more connected with other nearby regions (perhaps to compensate).pic.twitter.com/53P2dRT1WZ

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      12. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        12) Brain areas that were very strongly connected to other areas before the lesion (called hubs) were much more likely to lose connectivity after the lesion.pic.twitter.com/J4xKxdj86r

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      13. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        13) Others had shown that these hub regions were more likely to be affected in brain disorders, and suggested that it might just be easier to notice damage when it happens to hubs. Here we show that even when damage primarily affects non-hub areas, hubs are strongly affected.

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      14. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        14) Plasticity relies on the forming new or stronger connections between neurons, and this whole process relies on energy being delivered by other types of cells – glia, which were long considered the supporting act in the brain’s cell symphony.

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      15. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        15) We asked, could the density of neurons and glia in an area affect its ability to respond to damage elsewhere? The answer is yes, but this only seems to be important after the initial (acute) recovery has taken place.pic.twitter.com/tRAfhSs7DQ

        1 reply 0 proslijeđenih tweetova 2 korisnika označavaju da im se sviđa
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      16. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        16) The more glia in a brain area, the better it was able to increase its connectivity. It seems those oft-undermined support cells are important after all.

        1 reply 1 proslijeđeni tweet 5 korisnika označava da im se sviđa
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      17. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        17) Surprisingly, brain areas with more neurons packed in were more likely to become disconnected.pic.twitter.com/Xwc2KvJNW3

        1 reply 0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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      18. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        18) Neurons receive a lot of their connections on branches called dendrites. When lots of neurons are packed into an area, they tend to have smaller dendrites, and might be less able to change their connections after brain damage as a result.

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      19. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        19) In summary, how a brain region adapts after damage to another part of the brain depends on the mix of cell types in the area, and its connections with the damaged area and the rest of the brain.

        1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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      20. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        20) We think this will help us make more precise predictions about how the brain will change following damage, and hope this will help inform neuroscience-inspired treatments.

        1 reply 0 proslijeđenih tweetova 2 korisnika označavaju da im se sviđa
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      21. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        21) If you’re interested in how these lesions affected memory, you can check out our other recent paper with @markgbaxter & @crewilsonhttp://www.jneurosci.org/content/38/36/7800 …

        1 reply 1 proslijeđeni tweet 6 korisnika označava da im se sviđa
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      22. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        22) If you want to dig in further, all the data are freely available on PRIME-DE. That’s it, thanks for reading! ☺ https://www.sciencedirect.com/science/article/pii/S0896627318307682 …

        1 reply 0 proslijeđenih tweetova 9 korisnika označava da im se sviđa
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      23. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        Thanks also to @markgbaxter and @RudebeckLab from the Sinai crowd (now including star signings @erinLrich and @rajankdr ) for a huge amount of support, intellectual and otherwise.

        1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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      24. Sean Froudist-Walsh‏ @seanfw 21. stu 2018.
        • Prijavi Tweet

        And fab co-author @DrKathyVet who I just found out is on twitter!

        0 replies 0 proslijeđenih tweetova 6 korisnika označava da im se sviđa
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