Science Signaling

@scisignal

The Premier Journal of Cell Signaling in Physiology and Disease.

Joined April 2010

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  1. Pinned Tweet
    Jan 1

    Interactions that promote intestinal tumor formation, cellular mechanisms of cystic fibrosis disease, and the activation of an atypical kinase in this year’s first Science Signaling issue!

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  2. 15 hours ago

    Burkhardt lab identifies Crk family adaptor proteins are critical for T cell migration

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  3. 18 hours ago

    GPR35 promotes Na/K-ATPase function to increase glycolytic metabolism and cellular proliferation

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  4. 22 hours ago

    A polyunsaturated fatty acid activates sensory neurons and requires the GPCR Mrgprd to promote abdominal pain associated with IBS

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  5. Jan 3

    Yates Lab finds the most prevalent mutation in Cystic Fibrosis patients prevents phosphorylation necessary for CFTR chloride channel maturation

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  6. Jan 3

    Want to understand synaptic plasticity in learning and memory? Don’t miss the latest Review from Johannes Hell on AMPA receptor trafficking and postsynaptic localization

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  7. Jan 3

    Live-cell imaging reveals that the sphingolipid S1P activates atypical PKC to promote cell survival

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  8. Jan 2

    Posttranslational modification of the chloride channel CFTR correlates with the cellular response to therapy

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  9. Jan 2

    Independent of its traditional ligands, GPR35 interacts with the Na/K-ATPase pump to enhance intestinal tumor formation

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  10. Dec 31

    Covalent EGFR family inhibitors promote degradation of TRIB2 to kill cancer cells . Happy New Year's!

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  11. Dec 31

    This year, researchers uncovered a targetable HDAC3–SMARCA4–miR-27a axis that promotes PAX3:FOXO1 fusion oncogene expression in rhabdomyosarcoma

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  12. 31 Dec 2018

    Using CRISPR and siRNA, the Lefkowitz lab elucidated the manifold roles of β-arrestins in signaling

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  13. 31 Dec 2018

    cAMPr: A genetically encoded single-wavelength fluorescent sensor for cyclic AMP.

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  14. 31 Dec 2018

    A research group found that hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence.

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  15. 30 Dec 2018

    This year, a study from discovered that inhibitors of adenylyl cyclase increase melanosome pH, skin pigmentation, and may reduce skin cancer risk:

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  16. 30 Dec 2018

    In September, a study described how the kinases HipA and HipA7 phosphorylate different substrate pools in Escherichia coli to promote multidrug tolerance

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  17. 29 Dec 2018

    Adenosine inhibits the migration of T cells from cancer patients due to reduced KCa3.1 K+ channel activity

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  18. 28 Dec 2018

    In our July 3 issue, a study found inhibiting the acetyltransferase NAT10 rescued a nuclear import pathway in cells from Hutchinson-Gilford progeria syndrome patients.

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  19. 28 Dec 2018

    R-Ras2 stimulates tRNA expression necessary for mitochondrial biogenesis and GC B cell development

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  20. 27 Dec 2018

    As we count down to the new year, we'll be highlighting ten of our favorite research articles from 2018. Look out for tweets with the tag as we celebrate a year of great research!

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