Blake Smith

@science_blake

MD-PhD student | interested in all things immunology, chemical biology | Yale '16, NY native

Boston, MA
Vrijeme pridruživanja: rujan 2019.

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  1. prije 1 sat

    cytokine release syndrome (CRS) may not be limited to CAR-T cells themselves, but rather due to downstream effects of pyroptosis: cleavage & activation of gasdermin E (GSDME) in B cells -> downstream activation & cytokine release from macrophages -> CRS

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  2. 3. velj

    another major contribution from the Broad's cancer cell line encyclopedia (CCLE) effort: quantitative proteomics data on 375 cancer cell lines, open-source as always, to aid researchers in their quest to understand this disease

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  3. 1. velj

    encouraging data at 12 mo follow-up from 9 patients with chronic granulomatous disease who received phagocyte NADPH oxidase subunit gp91phox via autologous CD34+ HSC lentiviral delivery 6/9 patients showed no new infections & remain off prophylactic abx

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  4. 31. sij

    highlights from a great NYT piece on the 2019-nCoV: 1) transmission rate of ~1.5-3.5 people/infected individual (~1.3 for seasonal flu) 2) <3% fatality rate (10% for Spanish flu & SARS) 3) 2-14d asymptomatic incubation period 4) vaccination efforts underway but far away (~1 yr)

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  5. 31. sij

    a really clever way to fluorescently & covalently label proteins of interest (incl. nuclear hormone receptors) inside cells with a small molecule cyclization (lactonization) results in coumarin moiety & subsequent "turn-on" fluorescence of POI!

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  6. 26. sij
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  7. 26. sij

    a really impressive body of work dissecting out biochemical requirements for E3 ligase ternary complex efficiency; highly recommend those in the TPD field look at figs. 5 & 6 PIKES analysis can help tease out nuances of cell line differences, DC50s, etc.

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  8. 23. sij
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  9. 20. sij

    nice demonstration of in vivo clonal dynamics of infused CD8+ CD19-targeting CAR-T cells: these cell-based therapeutics respond to environmental cues (i.e. infusion into a patient), resulting in oligoclonal expansion & shifted transcriptional signatures

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  10. 20. sij

    flu season meets a new enemy: an emerging coronavirus (same +ssRNA viral family as SARS, MERS) in Wuhan, China there have now been >200 cases reported and the number is expected to rise with imminent Lunar New Year travel

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  11. 17. sij

    really wonderful piece from a chemist on his daughter's cancer diagnosis & the place that an unfettered childhood imagination can have for future treatment of disease thanks to for publishing; surely will motivate more fun structures!

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  12. 17. sij
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  13. 15. sij

    Regeneron's tumor-specific antigen (TSA)xCD3 bispecifics (signal 1) + TSAxCD28 costimulatory bispecifics (signal 2) show profound activity in an ovarian tumor model while sparing the non-specific superagonist activity of prior CD28 bivalent antibodies

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  14. 13. sij

    the rare patient-scientist can play an essential role in advancing treatment for their own disease: "Perhaps there is something peculiarly clarifying about defining success by honestly answering the question 'What would you want for your own brain?'"

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  15. 12. sij

    humbled to be at a pioneering institution and amazed by pioneering patients like Helen Obando whose bravery will pave the way for so many individuals (and younger children) who have sickle cell disease

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  16. 12. sij

    even though my eyes are closed here, this was quite the eye-opening talk from on her rare disease (Jansen's metaphyseal chondrodysplasia) and the essential role that patients play as advocates in advancing science, legislation, and biomedical translation to the clinic

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  17. 12. sij

    note-to-self as a trainee: "I suddenly understood that I was like some myopic thespian acting out a wartime drama on a real battlefield — posturing to impress with elegant soliloquies, impeccable costume, and false bravado, while real patients suffered."

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  18. 4. sij

    this is an incredible thread for anyone interested in drug dev/med chem be sure to check out post #3 for some really wacky protein-ligand molecular interactions, sourced from this JMC paper that Roche published using data from the PDB:

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  19. 2. sij

    vaccine nanoparticle containing antigen-encoding RNA to optimally stimulate CAR-T cells targeting this oncofetal tight junction protein (claudin 6) method provides a way for tunable expansion of CAR-T cells, especially in the context of solid tumors

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  20. 2. sij

    placing a bet that this form of chirality will haunt organic chemistry students by 2050

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