In terms of optimal virulence, parasitic organisms that rely on vertical transmission (parent-to-child ONLY) tend to evolve benign symbiosis
btw the optimal virulence stuff is not just my regular crackpottery it's crackpottery backed by S C I E N C E http://euplotes.biology.uiowa.edu/web/jmlpubls/slk05.pdf …
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