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sarahcobey's profile
Sarah Cobey
Sarah Cobey
Sarah Cobey
@sarahcobey

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Sarah Cobey

@sarahcobey

Computational epidemiology, evolution, influenza, SARS-CoV-2, vaccines, and B cells. Infectious disease dynamics across scales.

University of Chicago
cobeylab.uchicago.edu
Joined January 2008

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    1. Ralph Isberg‏ @IsbergRalph 1 Jan 2021

      Ralph Isberg Retweeted Natalie E. Dean, PhD

      This conversation makes me nervous about policy/driven viral immune escape mutants @nataliexdean @jbloom_lab @VirusesImmunity. A controlled trial seems unlikely to determine if lower antibody titers are more likely to select for escape mutants. Does anyone know?https://twitter.com/nataliexdean/status/1345032767529168897 …

      Ralph Isberg added,

      Natalie E. Dean, PhDVerified account @nataliexdean
      The conversation around vaccines feels jumbled because there are actually MANY policy ideas being floated: - One dose only vs. two doses spaced apart vs. two doses but don’t reserve the second in the freezer - Changes to Oxford vax vs. Pfizer/BioNTech (different evidence)
      Show this thread
      1 reply 5 retweets 24 likes
    2. Bloom Lab‏ @jbloom_lab 1 Jan 2021
      Replying to @IsbergRalph @nataliexdean @VirusesImmunity

      This is not known for global virus transmission. For within host viral evolution there may be some data. But global evolution is extremely complex due to transmission in an extremely heterogeneous human population. 1/3

      1 reply 2 retweets 26 likes
    3. Bloom Lab‏ @jbloom_lab 1 Jan 2021
      Replying to @jbloom_lab @IsbergRalph and

      @sarahcobey or @LauringLab might know more, but for influenza there is minimal evidence that vaccination affects antigenic evolution as even in absence of vaccine there is immune pressure from natural immunity. 2/3

      2 replies 4 retweets 21 likes
    4. Lauring Lab‏ @LauringLab 1 Jan 2021
      Replying to @jbloom_lab @IsbergRalph and

      FWIW our work in flu shows vax stimulated immunity (which in flu is partial and non sterilizing) imposed only a weak selective pressure within hosts. See also @McCroneIV eLife 2018. @sarahcobey can speak for pop level. Not strong selection there either?https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006194 …

      1 reply 3 retweets 14 likes
    5. Sarah Cobey‏ @sarahcobey 1 Jan 2021
      Replying to @LauringLab @jbloom_lab and

      We don't see strong selection for vaccine-induced evolution at the population level. Here's some work with Frank Wen, @sidneymbell, @trvrb from a few years ago:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165116/ …

      2 replies 3 retweets 10 likes
    6. Sarah Cobey‏ @sarahcobey 1 Jan 2021
      Replying to @sarahcobey @LauringLab and

      Here's some nice theory by Frank Wen and @anup_malani suggesting we shouldn't see accelerated antigenic evolution for a flu-like pathogen:https://www.biorxiv.org/content/10.1101/162545v4 …

      2 replies 7 retweets 24 likes
      Sarah Cobey‏ @sarahcobey 1 Jan 2021
      Replying to @sarahcobey @LauringLab and

      Overall, I completely agree with @jbloom_lab that managing viral evolution is a higher order problem that we eventually need to investigate, but there's no reason it should slow efforts to vaccinate now. Stronger and broader immunity now will only help.

      11:49 AM - 1 Jan 2021
      • 7 Retweets
      • 32 Likes
      • allgaeutrainer - 2xBNT,1xMDRN Leif Erik Sander Geoff Penington Michael Martin Tendency to Drift Katherine Schlag Stephen Berry Peter Hewitt Dr. Sidney Bell
      2 replies 7 retweets 32 likes
        1. This Tweet is unavailable.
        2. Brian Wasik‏ @BrianRWasik 1 Jan 2021
          Replying to @dylanhmorris @sarahcobey and

          ☝️re: population effects of transmitted variants. Vaccine-derived immunity may be biased in IgG classes that protect lungs on progression but not select URT transmitters D1-4 (IgA, IgM). Also <waves to Sarah> the vast complex nature of host immune bias from total past infections.

          0 replies 0 retweets 6 likes
        3. End of conversation
        1. New conversation
        2. Jessica Pickett‏ @pickettjessica 1 Jan 2021
          Replying to @sarahcobey @LauringLab and

          Thanks for a fascinating thread! Beyond immediate implications, though, many vaccine companies are already making strategic investments in the longer-term endemic market. With that in mind, should regulators modify the preferred profile to account for evolution going forward?

          1 reply 0 retweets 3 likes
        3. Omkar Venkatesh‏ @OmkarGV 1 Jan 2021
          Replying to @pickettjessica @sarahcobey and

          I think it's an interesting point for evaluating which vaccines to manufacture/buy. But in the near term, given shortages I'm guessing regulators are probably going to authorize any vaccine that demonstrates efficacy in the near term.

          0 replies 0 retweets 1 like
        4. End of conversation

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