.@sapinker @cfchabris Quite possible that main diffs b/w individuals due to multiple diverse rare alleles, not commonly segregating ones
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@sapinker@cfchabris Not currently possible to distinguish b/w massive polygenicity and heterogeneous oligogenicity for behavioural traits -
@WiringTheBrain does latter imply higher proportion of non-viable conceptuses than former?If so, not v competitive for some species (e.g us) -
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@bogglerapture Not sure that follows. But it's true that each gamete has many de novo mutations and some will result in non-viable fetuses -
@WiringTheBrain was thinking oligogenicity implies larger effects from indiv' variants so bigger chance of 'bad draw' than common var' model -
@bogglerapture Hmm, yes it does imply bigger effects - not sure about bad luck draw if just talking traits, but at some point --> disorders -
@WiringTheBrain ah I see. My thinking overlooked redundancy and interdependency of allelic effects + noise. So some context trait, other dx -
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@bogglerapture That means profiles of common SNPs or polygenic scores will be of very limited value in predicting individual phenotypes -
@WiringTheBrain@bogglerapture ...e.g., might schiz polygenic risk scores predict which individuals w del 22q11.2 end up w schizophrenia? - 3 more replies
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5th Law: It may not be the genes at all.
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