.@sapinker @cfchabris Pop'n genetic models that assume static pool of var'n far too simplistic - reality is highly dynamic spectrum
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@sapinker@cfchabris My point is complex traits may be affected by many diff variants in pop'n, but few meaningful ones per individualThanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker@cfchabris See these for more on dynamic spectrum of human genetic var'n: http://www.cell.com/abstract/S0092-8674%2811%2901062-2?switch=standard …, http://www.ncbi.nlm.nih.gov/pubmed/22657391Thanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker@cfchabris If trait under selection, does not => effect size small, => mut'ns of large effect rareThanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker@cfchabris Not one pool of variants doled out to all members of pop'n - many unique to individuals, families, clansThanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker@cfchabris Conclusion is not supported: -ve GWAS data do NOT => traits must be affected by many variants of very small effectThanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker Nice work. But pleeze: "Homo sapiens" with capital H and italicized, the Linnaean way.Thanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker We humans are complex! So many variables involved.Thanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker Still in 'The blank slate' fight? love your intellectual input but still not convinced me is both Nature and Nurture. Keep at itThanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker nice paper, I suppose that closing with a Yiddish expression was yours?Thanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker OK, who am I to tell you anything? Anyway, here's a funny paper about genes and attending med school: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1683595/pdf/ajhg00102-0142.pdf …Thanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker shouldn't there be some mention of epigenomics here?Thanks. Twitter will use this to make your timeline better. UndoUndo
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@sapinker Associating genetic markers with psych markers is very powerful but it ultimately turns development into a black box.#epigeneticsThanks. Twitter will use this to make your timeline better. UndoUndo
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