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Experts know the new coronavirus is not a bioweapon. They disagree on whether it could have leaked from a research lab thebulletin.org/2020/03/expert #biosafety

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Even most biologists are not aware that virologists have been experimentally recombining and genetically modifying coronaviruses for more than a decade to study their mechanisms of pathogenicity:

pubmed.ncbi.nlm.nih.gov

Manipulation of the coronavirus genome using targeted RNA recombination with interspecies chimeric...

Targeted RNA recombination has proven to be a powerful tool for the genetic engineering of the coronavirus genome, particularly in its 3' part. Here we describe procedures for the generation of...

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Here's an example from 20 years ago:

pubmed.ncbi.nlm.nih.gov

Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome - PubMed

The construction of cDNA clones encoding large-size RNA molecules of biological interest, like coronavirus genomes, which are among the largest mature RNA molecules known to biology, has been...

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Another: pubmed.ncbi.nlm.nih.gov/10627550/. Anyone check if they stopped doing this sort of thing before #COVID19 broke?

pubmed.ncbi.nlm.nih.gov

Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host...

Coronaviruses generally have a narrow host range, infecting one or just a few species. Using targeted RNA recombination, we constructed a mutant of the coronavirus mouse hepatitis virus (MHV) in...

7:41 PM · Apr 1, 2020