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salonium's profile
Saloni 🏳️‍🌈
Saloni 🏳️‍🌈
Saloni  🏳️‍🌈
@salonium

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Saloni  🏳️‍🌈

@salonium

PhD student in psychiatric genetics @HKUniversity @KingsCollegeLon. Memes @ASI. Tweets: genetics, psych, econ, polisci, etc. 🏳️‍🌈💜

香港
Joined January 2013

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    1. José Luis Ricón (Artir)‏ @ArtirKel Feb 5

      What's the best explainer for why chronic inflammation is bad? Not a paper that says that it correlates with (bad things) nor one that says why it happens, but just about the molecular mechanisms that lead from inflammation to damage.

      10 replies 4 retweets 32 likes
      Show this thread
    2. Alexey Guzey‏ @alexeyguzey Mar 1
      Replying to @ArtirKel

      related -- i know nothing about this but -- why the hell would you use "anti-inflammatory drugs"? isn't inflammation a response to a disease/bacteria/etc? why are you trying to interfere with the organism fighting back?

      3 replies 0 retweets 4 likes
    3. Saloni  🏳️‍🌈‏ @salonium Mar 1
      Replying to @alexeyguzey @ArtirKel

      Typically because inflammation can spiral out of control but also because inflammation can result from allergies, autoimmunity, etc not just infections

      1 reply 0 retweets 2 likes
    4. José Luis Ricón (Artir)‏ @ArtirKel Mar 1
      Replying to @salonium @alexeyguzey

      Yes, that would be a legitimate case, but for infections it seems one does want those histamines hanging around

      1 reply 0 retweets 0 likes
    5. Saloni  🏳️‍🌈‏ @salonium Mar 1
      Replying to @ArtirKel @alexeyguzey

      Well, not necessarily - immune responses to infection can also be excessive and harmful, e.g. https://en.wikipedia.org/wiki/Cytokine_release_syndrome?wprov=sfla1 …

      1 reply 0 retweets 1 like
    6. Saloni  🏳️‍🌈‏ @salonium Mar 1
      Replying to @salonium @ArtirKel @alexeyguzey

      Immune reactions to infections are adapted to being temporary in general, in case you wanted an adaptational perspective on it: https://en.wikipedia.org/wiki/Inflammation … (see the resolution to inflammation section)

      1 reply 0 retweets 0 likes
    7. Alexey Guzey‏ @alexeyguzey Mar 1
      Replying to @salonium @ArtirKel

      totally see the point for allergies and cytokine storm, but i believe anti-inflammatory drugs are used for a much larger variety of diseases, e.g. alzheimer's and parkinson's iirc?

      1 reply 0 retweets 1 like
    8. Saloni  🏳️‍🌈‏ @salonium Mar 1
      Replying to @alexeyguzey @ArtirKel

      Ohh. I'm not sure why that is either. It's thought that inflammation is involved in causing Alzheimer's / Parkinson's but IIRC some anti-inflammatory drugs are effective for them without us understanding the mechanisms behind why.

      1 reply 0 retweets 0 likes
    9. Alexey Guzey‏ @alexeyguzey Mar 1
      Replying to @salonium @ArtirKel

      my impression was that there are literally 0 drugs effective vs Alzheimer's?

      2 replies 0 retweets 1 like
      Saloni  🏳️‍🌈‏ @salonium Mar 1
      Replying to @alexeyguzey @ArtirKel

      sorry, you're right - I misremembered!

      10:18 PM - 1 Mar 2020
      • 1 Like
      • spirit_of_negation
      0 replies 0 retweets 1 like

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