Sandeep Venkataram

@s_venkataram

Evolutionary Biologist, Post-doctoral fellow, UCSD

Vrijeme pridruživanja: prosinac 2013.

Tweetovi

Blokirali ste korisnika/cu @s_venkataram

Jeste li sigurni da želite vidjeti te tweetove? Time nećete deblokirati korisnika/cu @s_venkataram

  1. proslijedio/la je Tweet
    4. pro 2019.

    Me pulling bacteria out of the -80 to evolve antibiotic resistance

    Tweet je nedostupan.
    Poništi
  2. proslijedio/la je Tweet

    Attention PhD students and recent PhDs in pop, evol or quant genetics, consider applying for the James F Crow award:

    Poništi
  3. proslijedio/la je Tweet
    29. stu 2019.

    Please RT: I'm hiring a Research Associate for my lab! Experimental co-evolution of fungi & algae + more (as RA is interested). If you know of excellent candidates, please encourage them to apply. Happy Holidays!

    Poništi
  4. proslijedio/la je Tweet
    26. stu 2019.

    My lab, in collaboration with at U Arizona, has a new preprint. The work was led by my fantastic postdoc . He describes the main results in this thread:

    Prikaži ovu nit
    Poništi
  5. proslijedio/la je Tweet
    25. stu 2019.

    Excited to share our latest preprint describing the lab evolution of bacteria with disrupted translation machinery! We introduce a term "Evolutionary Stalling", describing how natural selection acts on cellular modules, when they are disrupted, suboptimal:

    Prikaži ovu nit
    Poništi
  6. proslijedio/la je Tweet
    24. stu 2019.

    Checkout our newest preprint on the laboratory evolution of bacteria with a perturbed translation machinery, in collaboration with the Kryazhimskiy Lab at UCSD!

    Poništi
  7. 24. stu 2019.

    Hopefully the next paper (on adaptation in a yeast-algae mutualism) which and I will start writing in December, will be a bit more straightforward to write... (12/12)

    Prikaži ovu nit
    Poništi
  8. 24. stu 2019.

    Writing with and has been very educational, and I have definitely become a better writer and scientist from it. (11/12)

    Prikaži ovu nit
    Poništi
  9. 24. stu 2019.

    Do I wish we had finished this 2 months ago so I could have included it in many of my faculty apps? Absolutely. But I would much rather have a good paper than rush out something I wasn't satisfied with for the sake of my CV. (PS: Hire me!) (10/12)

    Prikaži ovu nit
    Poništi
  10. 24. stu 2019.

    had the good idea to pull this to the forefront and make the story revolve around it, because we realized that it had not really been explicitly tested in the literature before. An important lessen for me to constantly identify and validate assumptions! (9/12)

    Prikaži ovu nit
    Poništi
  11. 24. stu 2019.

    Finally, in October, we hit on the idea of evolutionary stalling. I had buried it in the discussion, about how mildly suboptimal TMs won't be expected to get adaptive mutations if there are larger-effect benefits to be gained from just adapting to the nutrient environment. (8/12)

    Prikaži ovu nit
    Poništi
  12. 24. stu 2019.

    Eventually it was September. I had been writing for basically 3 months solid, in between many conference trips. But the paper never really clicked. Every framing we tried was either uninteresting or unsupportable with our approach / data. (7/12)

    Prikaži ovu nit
    Poništi
  13. 24. stu 2019.

    What would the paper be about? The initial idea was to focus on our findings of epistasis in adaptation and the structure of the genotype-fitness landscape. Later versions were framed around the timing of TM optimization relative to LUCA, or later the cost of complexity (6/12)

    Prikaži ovu nit
    Poništi
  14. 24. stu 2019.

    Over the next 2 years, we established a good collaboration, evolving the populations for an additional 500 generations, sequencing them, measuring growth rate and competitive fitness, reconstructing mutations etc. We started writing May-June 2019. (5/12)

    Prikaži ovu nit
    Poništi
  15. 24. stu 2019.

    One of the 6 founders contains an ancestrally reconstructed version of EF-Tu (translation elongation factor). The original idea was to try and understand how this complex, ancient molecular machine had evolved, at least in gamma proteobacteria. (4/12)

    Prikaži ovu nit
    Poništi
  16. 24. stu 2019.

    She had evolved 10x replicates of 6 E. coli genotypes with different defects in the translation machinery (TM) for 500 gens, and had asked Sergey, who asked Shohreh our research scientist, to get these populations sequenced. I was brought in to do the sequencing analysis. (3/12)

    Prikaži ovu nit
    Poništi
  17. 24. stu 2019.

    My postdoc started Oct 2016. I had a different project I started with, before being added to this collaboration in Jan 2017. I didn't know at the time, she had been collaborating with my PI as she did not have expertise w/ microbial evo expts. (2/12)

    Prikaži ovu nit
    Poništi
  18. 24. stu 2019.

    In another thread, I go through the science of my new preprint (). Here I want to talk about the journey it took to get it to this stage (1/12)

    Prikaži ovu nit
    Poništi
  19. proslijedio/la je Tweet

    1. For the last few years we've been hearing a lot about *evidence-based teaching* practices. In principle, I'm a big fan of using evidence to improve my teaching. In practice, the majority of the evidence we are presented with is deeply problematic.

    Prikaži ovu nit
    Poništi
  20. 24. stu 2019.

    This project has been quite a journey, thanks to my wonderful advisers and collaborators, esp and for helping make this happen! (9/9)

    Prikaži ovu nit
    Poništi

Čini se da učitavanje traje već neko vrijeme.

Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.

    Možda bi vam se svidjelo i ovo:

    ·