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Sandeep Venkataram proslijedio/la je Tweet
Me pulling bacteria out of the -80 to evolve antibiotic resistance https://twitter.com/s8n/status/1198250267722039296 …
Tweet je nedostupan.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Sandeep Venkataram proslijedio/la je Tweet
Attention PhD students and recent PhDs in pop, evol or quant genetics, consider applying for the
@GeneticsGSA James F Crow award:https://twitter.com/GeneticsGSA/status/1201610239516315649 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Sandeep Venkataram proslijedio/la je Tweet
Please RT: I'm hiring a Research Associate for my lab! Experimental co-evolution of fungi & algae + more (as RA is interested). If you know of excellent candidates, please encourage them to apply. Happy Holidays! http://darwinsdaemon.com/openings.php
#homlabHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Sandeep Venkataram proslijedio/la je Tweet
My lab, in collaboration with
@betulland at U Arizona, has a new preprint. The work was led by my fantastic postdoc@s_venkataram. https://www.biorxiv.org/content/10.1101/850644v1 … He describes the main results in this thread:https://twitter.com/s_venkataram/status/1198702231878619136 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Sandeep Venkataram proslijedio/la je Tweet
Excited to share our latest preprint describing the lab evolution of bacteria with disrupted translation machinery! We introduce a term "Evolutionary Stalling", describing how natural selection acts on cellular modules, when they are disrupted, suboptimal:https://www.biorxiv.org/content/10.1101/850644v1 …
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Sandeep Venkataram proslijedio/la je Tweet
Checkout our newest preprint on the laboratory evolution of bacteria with a perturbed translation machinery, in collaboration with the Kryazhimskiy Lab at UCSD! https://www.biorxiv.org/content/10.1101/850644v1 …
@s_venkataram@skryazhiHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Hopefully the next paper (on adaptation in a yeast-algae mutualism) which
@skryazhi and I will start writing in December, will be a bit more straightforward to write... (12/12)Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Writing with
@skryazhi and@betulland has been very educational, and I have definitely become a better writer and scientist from it. (11/12)Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Do I wish we had finished this 2 months ago so I could have included it in many of my faculty apps? Absolutely. But I would much rather have a good paper than rush out something I wasn't satisfied with for the sake of my CV. (PS: Hire me!) (10/12)
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@skryazhi had the good idea to pull this to the forefront and make the story revolve around it, because we realized that it had not really been explicitly tested in the literature before. An important lessen for me to constantly identify and validate assumptions! (9/12)Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Finally, in October, we hit on the idea of evolutionary stalling. I had buried it in the discussion, about how mildly suboptimal TMs won't be expected to get adaptive mutations if there are larger-effect benefits to be gained from just adapting to the nutrient environment. (8/12)
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Eventually it was September. I had been writing for basically 3 months solid, in between many conference trips. But the paper never really clicked. Every framing we tried was either uninteresting or unsupportable with our approach / data. (7/12)
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What would the paper be about? The initial idea was to focus on our findings of epistasis in adaptation and the structure of the genotype-fitness landscape. Later versions were framed around the timing of TM optimization relative to LUCA, or later the cost of complexity (6/12)
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Over the next 2 years, we established a good collaboration, evolving the populations for an additional 500 generations, sequencing them, measuring growth rate and competitive fitness, reconstructing mutations etc. We started writing May-June 2019. (5/12)
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One of the 6 founders contains an ancestrally reconstructed version of EF-Tu (translation elongation factor). The original idea was to try and understand how this complex, ancient molecular machine had evolved, at least in gamma proteobacteria. (4/12)
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She had evolved 10x replicates of 6 E. coli genotypes with different defects in the translation machinery (TM) for 500 gens, and had asked Sergey, who asked Shohreh our research scientist, to get these populations sequenced. I was brought in to do the sequencing analysis. (3/12)
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My postdoc started Oct 2016. I had a different project I started with, before being added to this collaboration in Jan 2017. I didn't know
@betulland at the time, she had been collaborating with my PI@skryazhi as she did not have expertise w/ microbial evo expts. (2/12)Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
In another thread, I go through the science of my new preprint (https://www.biorxiv.org/content/10.1101/850644v1 …). Here I want to talk about the journey it took to get it to this stage (1/12)
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Sandeep Venkataram proslijedio/la je Tweet
1. For the last few years we've been hearing a lot about *evidence-based teaching* practices. In principle, I'm a big fan of using evidence to improve my teaching. In practice, the majority of the evidence we are presented with is deeply problematic.
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This project has been quite a journey, thanks to my wonderful advisers and collaborators, esp
@betulland and@skryazhi for helping make this happen! (9/9)Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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