Or with etazolate: https://www.ndineuroscience.com/userfiles/Etazolate%20EU%20J%20PHARM%202010-4.pdf …
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Or with a MAPK inhibitor:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923728/ …
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Or montelukast:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639806/ …
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Basically, improving cognition in aged rodents, even all the way down to young levels, is not that unusual. And doesn’t always translate to humans. (Neuroprotective drugs have a really bad translation track record.)
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I still think it’s a good sign! But keep in mind that lab rats are kept in the rat equivalent of prison. You can improve cognitive performance just by giving them an exercise wheel or toys or other rats to interact with.
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Also of course there are lots of interventions that reduce inflammation, oxidative stress, and blood glucose and lipids. Dietary restriction being the most famous.
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The “wow factor” on this paper seems to be from the fact that it claims reversal on epigenetic clocks. And epigenetic clocks are (IMHO) bad.
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Replying to @ArtirKel
They don’t predict mortality or disease very well in longitudinal samples. Also they’re neither causal nor something we inherently care about (like diseases & symptoms.)
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Replying to @s_r_constantin
Sounds like there should be a blogpost about this I could do (?) If you haven't already
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