I can criticize the methylation clocks all day. They’re trained on chronological age not remaining time to mortality, so not what we care about.
-
-
Even if you disagree, epigenetic clocks are *new*. The reason a bajillion other interventions haven’t been found to improve them isn’t because few things work but because few things have been tested on these new metrics.
Show this thread -
My reaction is “ok, add this mystery intervention to the list of ~100 things that seem like they might do something to aging symptoms in mammals”. I’m not sure where Josh Mitteldorf’s extreme endorsement is coming from here.
Show this thread
End of conversation
New conversation -
-
-
What's your key beef with epigenetic clocks?
-
They don’t predict mortality or disease very well in longitudinal samples. Also they’re neither causal nor something we inherently care about (like diseases & symptoms.)
- 2 more replies
New conversation -
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.