Lower chronic inflammation— this is also a good sign. IL-6 correlates with pretty much every chronic disease of aging and long-lived mouse strain.pic.twitter.com/9hYhk3qIX0
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Also of course there are lots of interventions that reduce inflammation, oxidative stress, and blood glucose and lipids. Dietary restriction being the most famous.
The “wow factor” on this paper seems to be from the fact that it claims reversal on epigenetic clocks. And epigenetic clocks are (IMHO) bad.
Even if you disagree, epigenetic clocks are *new*. The reason a bajillion other interventions haven’t been found to improve them isn’t because few things work but because few things have been tested on these new metrics.
My reaction is “ok, add this mystery intervention to the list of ~100 things that seem like they might do something to aging symptoms in mammals”. I’m not sure where Josh Mitteldorf’s extreme endorsement is coming from here.
(relatable tbqfh)
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