guys you know what actually *does* reduce death rates in COVID-19? ivermectin! 1.4% vs 8.5% mortality in case-control study of 1408 pts. https://poseidon01.ssrn.com/delivery.php?ID=300072021025000071109084107113125113025005005004070018073117120117026088108022106109117103025024123046008106069105002004015114017060093009000090101092014006102003022017093095121089020090101088031006020113076088103028077104124082113106024104094119082101&EXT=pdf …
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Replying to @halvorz @s_r_constantin
150 ug/kg dosage seems way too low to have an effect (judging from the in vitro data) unless it's got really funky pharmacokinetics
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Replying to @halvorz @s_r_constantin
I agree but it’s very safe and very cheap I say let the RCTs go brrrrr
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I did a bit of research on Ivermectin and found this very interesting bit from this paper: https://www.cell.com/trends/parasitology/fulltext/S1471-4922(17)30062-4 … Could this have something to with IVM's efficacy, even at low doses?pic.twitter.com/40HF4eJGX3
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interesting although this is data for how it works against filarial worms, whether the antiviral mechanism at play has anything in common with the antifilarial mechanism is unclear to me if it's partly immunomodulatory, maybe
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at this point I just assume that antimicrobials are as likely to work through immunomodulation as through actually killing the critter
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until you actually go check, of course
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