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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin May 3
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      Look; this means *mechanism is bullshit*. An antiviral that “works” but doesn’t decrease viral load? Sure, I guess, it can have a different mechanism, but given how often this happens, should we really be framing drugs as having “known” MOAs at all?

      2 replies 2 retweets 25 likes
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    2. Sarah Constantin‏ @s_r_constantin May 3
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      I don’t want to stake out a strong position on “remdesivir is Never good to give a patient” but look, 30% reduction in time to recovery in severe patients, no mortality benefit, is not a cure.

      3 replies 2 retweets 20 likes
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    3. Sarah Constantin‏ @s_r_constantin May 3
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      Remdesivir is not gonna make it safe for everyone to go back to work. It’s just not that big an effect. And we desperately need an effect that big.

      2 replies 2 retweets 16 likes
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    4. Sarah Constantin‏ @s_r_constantin May 3
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      Except now, as @MarkHoofnagle notes, remdesivir is “standard of care” & now every other drug has to prove noninferiority! Nice power grab, Gilead!

      1 reply 0 retweets 34 likes
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    5. Sarah Constantin‏ @s_r_constantin May 3
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      This means “standard of care” is also bullshit, if you didn’t know. It’s a negotiation between power players, not a sober assessment of the science.

      1 reply 7 retweets 62 likes
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    6. Sarah Constantin‏ @s_r_constantin May 3
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      This is #regulatorycapture in action. Remdesivir, from all I can see, was a reasonable drug to try against #COVID19. There are lots of other reasonable drugs to try. Only the ones with deep pockets and good political relationships will get approved.

      1 reply 13 retweets 45 likes
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    7. Sarah Constantin‏ @s_r_constantin May 3
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      And then people will say “Science Says these are the good drugs and the others are bad” but never ask who determines *which* science gets done

      1 reply 0 retweets 28 likes
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    8. Sarah Constantin‏ @s_r_constantin May 3
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      What ordinary lay humans care about — can this drug save lives? can it make #COVID19 close to harmless? — is not even being tested!!!

      1 reply 0 retweets 17 likes
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    9. Sarah Constantin‏ @s_r_constantin May 3
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      “Hydroxychloroquine doesn’t have an RCT and remdesivir does!” Yes, true, and ALSO notice that hydroxychloroquine is a cheap generic so there’s nobody to *pay* for a big RCT.

      3 replies 4 retweets 36 likes
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    10. Lucre Snooker‏ @LucreSnooker May 4
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      Replying to @s_r_constantin

      but Gilead didn’t even pay for the remdesivir trial; NIH did. And there are 165 studies on clinical http://trials.gov  for HCQpic.twitter.com/gt2QE28YUT

      1 reply 0 retweets 4 likes
      Sarah Constantin‏ @s_r_constantin May 4
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      Replying to @LucreSnooker

      whoa, that is a lot of HCQ studies. I didn't know that. i was just going on bitter cynic priors. good to know!

      12:06 PM - 4 May 2020
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      • wily mandala Nabeel Qureshi Jim O’Neill halvorz ¯\_(ツ)_/¯
      0 replies 0 retweets 4 likes

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