Look; this means *mechanism is bullshit*. An antiviral that “works” but doesn’t decrease viral load? Sure, I guess, it can have a different mechanism, but given how often this happens, should we really be framing drugs as having “known” MOAs at all?
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I don’t want to stake out a strong position on “remdesivir is Never good to give a patient” but look, 30% reduction in time to recovery in severe patients, no mortality benefit, is not a cure.
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Remdesivir is not gonna make it safe for everyone to go back to work. It’s just not that big an effect. And we desperately need an effect that big.
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Except now, as
@MarkHoofnagle notes, remdesivir is “standard of care” & now every other drug has to prove noninferiority! Nice power grab, Gilead!1 reply 0 retweets 34 likesShow this thread -
This means “standard of care” is also bullshit, if you didn’t know. It’s a negotiation between power players, not a sober assessment of the science.
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This is
#regulatorycapture in action. Remdesivir, from all I can see, was a reasonable drug to try against#COVID19. There are lots of other reasonable drugs to try. Only the ones with deep pockets and good political relationships will get approved.1 reply 13 retweets 45 likesShow this thread -
And then people will say “Science Says these are the good drugs and the others are bad” but never ask who determines *which* science gets done
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What ordinary lay humans care about — can this drug save lives? can it make
#COVID19 close to harmless? — is not even being tested!!!1 reply 0 retweets 17 likesShow this thread -
“Hydroxychloroquine doesn’t have an RCT and remdesivir does!” Yes, true, and ALSO notice that hydroxychloroquine is a cheap generic so there’s nobody to *pay* for a big RCT.
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Replying to @s_r_constantin
but Gilead didn’t even pay for the remdesivir trial; NIH did. And there are 165 studies on clinical http://trials.gov for HCQpic.twitter.com/gt2QE28YUT
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whoa, that is a lot of HCQ studies. I didn't know that. i was just going on bitter cynic priors. good to know!
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