What ordinary lay humans care about — can this drug save lives? can it make #COVID19 close to harmless? — is not even being tested!!!
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“Hydroxychloroquine doesn’t have an RCT and remdesivir does!” Yes, true, and ALSO notice that hydroxychloroquine is a cheap generic so there’s nobody to *pay* for a big RCT.
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And the public only knows about hydroxychloroquine because there’s this one doc with a bee in his bonnet about it (and he’s probably biased and sloppy and goes to the media too early and exaggerates.)
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If it’s a cheap generic that *doesn’t* have a crazed fanboy, it’ll have even less apparent “success.” When was the last time you heard Discourse about indomethacin or niclosamide?
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If you don’t like that the “standard of care” is biased towards the interests of a handful of pharma companies...maybe the problem is that you need to be a hundred-billion-dollar company to run a clinical trial that satisfies today’s FDA?
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Replying to @s_r_constantin
Is there any account of folks in positions of influence soberly realizing that the FDA can do more harm than good as a result of the pandemic?
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Replying to @maxefremov
The FDA has loosened many of its usual restrictions because of the pandemic. The concept of risk-benefit tradeoffs is, I expect, very familiar to them. “Deregulation can ever be good” is clearly a notion the Trump administration has heard of.
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Replying to @s_r_constantin @maxefremov
Actually deregulating to the extent I support would require what is commonly called “fanaticism” — willingness to keep pushing against resistance to the point of becoming a boor — which I think is selected against in all leadership positions, public or private.
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Replying to @s_r_constantin @maxefremov
“I don’t care how nice, smart, or “reasonable” you are, I’m not gonna accept your excuses until the cost (or death rate, or w/e) goes down” is the attitude you need here.
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I don’t know anything but his media reputation, not even people’s experiences working at Tesla or SpaceX, but it sure sounds like he got 10x cost savings on rockets through fanaticism
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Replying to @s_r_constantin @maxefremov
This is from asking 2-3 people that work under him; lots of pressure, insistence beyond what initially seems reasonable, firing those he thinks are not performing
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People made fun of him for that acronyms post a while back but I think this is exactly the kind of thing that "fanatical" leaders do. Most people wouldn't bother for fear of being made fun of or being thought boorish/overly pedantic, etc. (https://gist.github.com/klaaspieter/12cd68f54bb71a3940eae5cdd4ea1764 …)
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