Ok so here’s the news report (I couldn’t find a paper) showing Remdesivir improves time to recovery in #COVID19https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19 …
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And here’s the Lancet study from China showing no mortality benefit from remdesivir:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31022-9/fulltext?utm_campaign=tlcoronavirus20&utm_source=twitter&utm_medium=social …
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You’ll notice the NIH study...also doesn’t show a statistically significant mortality benefit for remdesivir!!
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As
@MarkHoofnagle pointed out, remdesivir is supposed to work via viral replication inhibition; it prevents RNA viruses from copying their genetic material.1 reply 0 retweets 12 likesShow this thread -
This means a trial on advanced
#COVID19 patients was never gonna tell us jack shit. Viral load in this disease peaks around the onset of symptoms!!3 replies 0 retweets 22 likesShow this thread -
If your drug works by killing virus or blocking it from replicating, you’ve got to test it on *brand new* cases!
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(Mea culpa; I could have known this trial was gonna suck before the results came out, based on trial design, but I didn’t check.)
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Look; this means *mechanism is bullshit*. An antiviral that “works” but doesn’t decrease viral load? Sure, I guess, it can have a different mechanism, but given how often this happens, should we really be framing drugs as having “known” MOAs at all?
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I don’t want to stake out a strong position on “remdesivir is Never good to give a patient” but look, 30% reduction in time to recovery in severe patients, no mortality benefit, is not a cure.
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Replying to @s_r_constantin
30% reduction is good than nothing. say from 15 to 11 days recovery. this also could lead to mortality, right? The longer you got sick, the higher is the probability to die? - it also says reduce mortality from 11% to 8%. So, it is 'good enough' drug for now.
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Good enough to use? Yeah maybe. Good enough to end quarantine? No. Good enough to justify making it harder to approve other drugs? HELL NO.
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Replying to @s_r_constantin
Yup good enough to use definitely. It is still the first iteration of the whole arsenal of drugs.
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